Fig. 3From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus Case of melanoma in situ negative by fluorescence in-situ hybridization (FISH) detection. a Melanocytes proliferated successively or in nests in the basal layer of the epidermis (hematoxylin and eosin, H&E staining),(b) high-power magnification showed moderate atypia of the melanocytes with mitotic figures, which were easy to identify (black arrow)(H&E staining), (c-f) FISH images showed normal copies ofCCND1 (c, green signals), RREB1 (d, red signals), CEP6 (e, aqua signals), and MYB (f, gold signals) in tumor cells (white arrows)Back to article page