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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

Fig. 4

Case of compound nevus positive by fluorescence in-situ hybridization (FISH) detection. a Melanocytes scattered in the basal layer of the epidermis and proliferated without maturation in the dermis (hematoxylin and eosin, H&E staining), (b) high-power magnification showed mild atypia of the melanocytes and no mitotic Fig. (H&E staining),(c-f) FISH images showed the (c) gain of CCND1 (green signals), (d) gain of RREB1 (red signals),while the gain of RREB1(d, red signals) relative to CEP6 (e, aqua signals) or loss of MYB (f, gold signals) relative to CEP6 (e, aqua signals) was not observed

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Diagnostic Pathology

ISSN: 1746-1596

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