Skip to main content

Table 1 Clinicopathological feature of dysplastic nevi and early-stage acral and cutaneous melanomas

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

Feature

DN(50 cases), n(%)

Melanoma(59cases), n(%)

pa value

Gender ratio (male:female)

20:30 (0.67:1)

25:34 (0.74:1)

.802

Age, range (mean)

3–70 (36.60)

9–76 (47.73)

< .001*

Site

 Acral

31 (62.0)

42 (71.2)

.169

 Trunk

9 (18.0)

6 (10.3)

 

 Limb

9 (18.0)

6 (10.2)

 

 Others

1 (2.0)

5 (8.5)

 

mitotic figures≥1/mm2

1 (2.0)

23 (39.0)

< .001*

Diameter, range (mean, mm)

1–20 (7.30)

2–40 (11.34)

.002*

Stratum corneum pigmentation

17 (34.0)

38 (64.4)

.002*

Moderate to severe lymphocyte infiltration

6 (12.0)

28 (47.5)

< .001*

Moderate to severe cell atypia

6 (12.0)

52 (88.1)

< .001*

Melanocyte growth pattern in the epidermis

 Concessive distribution

20 (40.0)

48 (81.4)

< .001*

 Pagetoid spread

2 (4.0)

20 (33.9)

< .001*

 Nested distribution

33 (66.0)

44 (74.6)

.327

 Scattered distribution

37 (74.0)

26 (44.1)

.002*

  1. Abbreviations: DN dysplastic nevus, n number
  2. ap values from Pearson’s chi-square test, independent t-test. *p < .05, considered statistically significant