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Table 1 Clinicopathological feature of dysplastic nevi and early-stage acral and cutaneous melanomas

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

FeatureDN(50 cases), n(%)Melanoma(59cases), n(%)pa value
Gender ratio (male:female)20:30 (0.67:1)25:34 (0.74:1).802
Age, range (mean)3–70 (36.60)9–76 (47.73)< .001*
Site
 Acral31 (62.0)42 (71.2).169
 Trunk9 (18.0)6 (10.3) 
 Limb9 (18.0)6 (10.2) 
 Others1 (2.0)5 (8.5) 
mitotic figures≥1/mm21 (2.0)23 (39.0)< .001*
Diameter, range (mean, mm)1–20 (7.30)2–40 (11.34).002*
Stratum corneum pigmentation17 (34.0)38 (64.4).002*
Moderate to severe lymphocyte infiltration6 (12.0)28 (47.5)< .001*
Moderate to severe cell atypia6 (12.0)52 (88.1)< .001*
Melanocyte growth pattern in the epidermis
 Concessive distribution20 (40.0)48 (81.4)< .001*
 Pagetoid spread2 (4.0)20 (33.9)< .001*
 Nested distribution33 (66.0)44 (74.6).327
 Scattered distribution37 (74.0)26 (44.1).002*
  1. Abbreviations: DN dysplastic nevus, n number
  2. ap values from Pearson’s chi-square test, independent t-test. *p < .05, considered statistically significant