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Table 2 Number and percentage of cases meeting each diagnostic criterion of Gerami and Gaiser for dysplastic nevi and early-stage acral and cutaneous melanomas

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

 DN, n(%)melanoma, n(%)
Total, n5059
Gerami’s criteria
 RREB1 > CEP6 (> 55%)09 (15.3)
 RREB1 > 2 (> 29%)3 (6.0)44 (74.6)
 MYB<CEP6 (> 40%)1 (2.0)24 (40.7)
 CCND1 > 2 (> 38%)3 (6.0)54 (91.5)
 FISH positive3 (6.0)56 (94.9)
Gaiser’s criteria
 RREB1 aberrant (> 63%)3 (6.0)28 (47.5)
 MYB<CEP6 (> 31%)1 (2.0)30 (50.8)
 MYB ≥ 2.53 (6.0)28 (47.5)
 CCND1 ≥ 2.53 (6.0)52 (88.1)
 FISH positive5 (10.0)55 (93.2)
  1. Abbreviations: DN dysplastic nevus, n number