Skip to main content

Table 4 Comparison of the number and percentage of cases meeting each criterion of Gerami and Gaiser, and CCND1 amplification between the acral and non-acral groups of melanoma

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

 Acral group, n(%)Non-acral group, n(%)pa value
Total4217 
Gerami’s criteria
 RREB1 > CEP6 (> 55%)6 (14.3)3 (17.6)1.000
 RREB1 > 2 (> 29%)33 (78.6)11 (64.7).437
 MYB<CEP6 (> 40%)19 (45.2)5 (29.4).262
 CCND1 > 2 (> 38%)40 (95.2)14 (82.4).274
 FISH positive41 (97.6)15 (88.2).197
Gaiser’s criteria
 RREB1 aberrant (> 63%)22 (52.4)6 (35.3).234
 MYB<CEP6 (> 31%)21 (50.0)9 (52.9).838
 MYB ≥ 2.521 (50.0)7 (41.2).539
 CCND1 ≥ 2.539 (92.9)13 (76.5).187
 FISH positive40 (95.2)15 (88.2).691
 CCND1 copy numbers per cell,mean3.743.03.073
 Percentage of cells with CCND1 > 2,mean76.74%58.67%.007*
  1. Abbreviations: n number
  2. ap values from Pearson’s chi-square test, independent t-test. *p < .05, considered statistically significant