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Table 1 Clinicopathologic and molecular features of 27 patients with multiple sporadic GISTs

From: Clinicopathologic characteristics, diagnostic clues, and prognoses of patients with multiple sporadic gastrointestinal stromal tumors: a case series and review of the literature

No

Age/Sex

Site/size (cm)/MF/Risk

Histotype

Mutation status

Imatinib/follow-up/months

1a

60/F

ST/0.8/≤5/VLR

Spindle

NA

No/NED/120

1b

ST/2/≤5/VLR

Spindle

NA

2a

71/F

ST/1/≤5/VLR

Spindle

NA

No/NED/108

2b

ST/2/≤5/VLR

Spindle

NA

3a

75/F

ST/0.4/≤5/VLR

Spindle

NA

No/Died of GC/34

3b

ST/0.5/≤5/VLR

Spindle

NA

4a

54/F

ST/1/≤5/VLR

Spindle

NA

No/NED/104

4b

ST/1.2/≤5/VLR

Mix

NA

5a

62/F

ST/1/≤5/VLR

Spindle

NA

No/NED/102

5b

ST/1/≤5/VLR

Spindle

NA

6a

47/F

ST/3.5/< 5/LR

Spindle

KIT: p.V560del

No/NED/86

6b

ST/2/≤5/VLR

Spindle

KIT: p.V559D

7a

63/M

ST/2/≤5/VLR

Spindle

KIT: p.V559A

No/NED/60

7b

ST/0.5/≤5/VLR

Spindle

KIT: p.K642E

8a

65/F

ST/1.5/≤5/VLR

Epithelioid

PDGFRA: p.D842V

No/NED/58

8b

ST/1/≤5/VLR

Spindle

KIT: p.L576P

9a

61/M

ST/3.5/≤5/LR

Spindle

KIT: p.W557G

No/NED/54

9b

ST/1.5/≤5/VLR

Spindle

Wild type

10a

71/F

ST/3.5/≤5/LR

Spindle

KIT: p.L576P

No/NED/12

10b

ST/0.5/≤5/VLR

Spindle

KIT: p.V559G

11a

68/F

ST/1/≤5/VLR

Spindle

KIT: p.W557_E561del

No/NED/43

11b

ST/0.8/≤5/VLR

Spindle

KIT: p.V559_V560del

12a

70/F

ST/3.8/≤5/LR

Spindle

KIT: p.W557R

No/NED/34

12b

ST/1/≤5/VLR

Spindle

KIT: p.V560D

13a

72/F

SI/1.2/≤5/VLR

Spindle

KIT: p.L576P

No/Died of CC/34

13b

SI/0.8/≤5/VLR

Spindle

KIT p.D579del

14a

65/M

ST/4/≤5/LR

Mix

NA

No/NED/148

14b

ST/1/≤5/VLR

Mix

NA

15a

77/F

ST/5/≤5/LR

Mix

PDGFRA: p.D842V

No/NED/18

15b

ST/2/≤5/VLR

Spindle

KIT: p.N822K

16a

67/M

ST/5/≤5/LR

Spindle

KIT: p.V560del

No/NED/6

16b

ST/0.7/≤5/VLR

Spindle

KIT: p.L576P

17a

74/F

ST/4/≤5/LR

Spindle

KIT: p.W557_K558del

No/NED/4

17b

ST/1/≤5/VLR

Spindle

Wild type

17c

ST/0.3/≤5/VLR

Spindle

NA

18a

70/F

ST/1.8/≤5/VLR

Spindle

KIT: p.W557R

No/NED/12

18b

ST/1/≤5/VLR

Spindle

KIT: p.D820Y

18c

ST/0.7/≤5/VLR

Spindle

KIT: p.Q556_I563del

19a

71/M

ES/2.5/≤5/LR

Spindle

KIT: p.P577_H580dup

No/DUNC/25

19b

ES/1.5/≤5/VLR

Spindle

KIT: p.W557_V559indelF

20a

58/F

ST/6/≤5/IR

Spindle

KIT: p.Y578_H580dup

Yes/NED/52

20b

ST/8/≤5/IR

Spindle

KIT: p.W558_E561del

21a

76/F

ST/2.5/≤5/LR

Spindle

KIT: p.P577_H580dup

No/NED/32

21b

ST/4.5/6–10/IR

Spindle

KIT: p.M552_W557del

22a

69/M

ST/7/≤5/IR

Spindle

KIT: p.W557R

Yes/NED/10

22b

ST/3.5/≤5/LR

Spindle

KIT: p.V560E

23a

63/M

ST/6.5/≤5/IR

Spindle

KIT: p.P551_M552del

Yes/NED/48

23b

ST/5.2/≤5/IR

Spindle

KIT: p.I571_D579dup

24a

65/M

SI/6.5/≤5/HR

Spindle

KIT: p.G565_L576del

Yes/NED/8

24b

SI/5.5/≤5/HR

Spindle

KIT: p.A502_Y503dup

24c

SI/1.2/≤5/VLR

Spindle

KIT: p.W557R

25a

70/F

ST/13/6–10/HR

Spindle

KIT: p.L576_D579dup

Yes/NED/5

25b

ST/1.5/≤5/VLR

Epithelioid

PDGFRA: p.D842Y

26a

61/F

SI/7/≤5/HR

Spindle

KIT: p.N566_T574del

Yes/NED/62

26b

SI/5/≤5/LR

Spindle

KIT: p.V560E

a27a

71/M

ST/2/≤5/VLR

Spindle

KIT: p.W557_K558del

No/NED/42

a27b

ST/1/≤5/VLR

Spindle

KIT: p.K642E

a27c

ST/6/> 10/HR

Spindle

KIT:p.A502_Y503dup

Yes/NED/18

  1. Abbreviation: MF, Mitotic count per 50 high power field, ST Stomach, SI Small intestine, ES Esophagus, Risk Risk assessment according to modified NIH scheme, VLR Very low risk, LR Low risk, IR Intermediate risk, HR High risk, NA Not available, NED No evidence of disease, DUNC Died of unknown cause, GC Gastric cancer, CC Colon cancer
  2. aCase 27: The patient had metachronous GISTs. He had two GIST lesions in the stomach initially. Then, he developed another GIST in the stomach 42 months after the first surgery. We did not think it was a recurrence because the genotype of this tumor was different from that of the previous two lesions