Table 2 Clinicopathologic and molecular features of 11 patients with metastatic GISTs mimicking multiple sporadic GISTs
No | Age/Sex | Site/size (cm)/MF/Risk | Histotype | Mutation status | Imatinib/ follow-up/months |
|---|---|---|---|---|---|
1a | 43/M | SI/6.5/> 10/HR | Spindle | KIT: p.W557_K558del | Yes/NED, 12 |
1b | SI/3.5/> 10/HR | Spindle | KIT: p.W557_K558del | ||
1c | SI/1/> 10/HR | Spindle | KIT: p.W557_K558del | ||
2a | 67/F | ST/14/≤5/HR | Spindle | KIT: p.W557_K558indelE | Yes/AWD/37 |
2b | ST/1/≤5/VLR | Spindle | KIT: p.W557_K558indelE | ||
3a | 65/M | SI/11.5/≤5/HR | Spindle | KIT: p.A502_Y503dup | Yes/NED/35 |
3b | SI/6.5/≤5/HR | Spindle | KIT: p.A502_Y503dup | ||
4a | 66/F | ST/4.5/> 10/HR | Spindle | KIT: p.K558_V559del | Yes/DOD/68 |
4b | ST/3/> 10/HR | Spindle | KIT: p.K558_V559del | ||
5a | 69/M | SI/9/≤5/HR | Spindle | KIT: p.V559D | Yes/AWD/89 |
5b | SI/6/≤5/HR | Spindle | KIT: p.V559D | ||
6a | 73/M | ST/5/> 10/HR | Spindle | KIT: p.V555_V559del | Yes/NED/16 |
6b | ST/3.5/> 10/HR | Spindle | KIT: p.V555_V559del | ||
7a | 39/F | VA/2.5/> 10/HR | Spindle | KIT: p. K558del | Yes/AWD/12 |
7b | VA/2.5/> 10/HR | Spindle | KIT: p. K558del | ||
8a | 56/F | ME/3.5/6–10/HR | Spindle | KIT: p.A502_Y503dup | Yes/AWD/46 |
8b | ME/1.5/6–10/IR | Spindle | KIT: p.A502_Y503dup | ||
8c | ME/1/6–10/IR | Spindle | KIT: p.A502_Y503dup | ||
9a | 65/M | SI/11/> 10/HR | Spindle | KIT: p.Y553_K558del | No/DOD/18 |
9b | SI/9/> 10/HR | Spindle | KIT: p.Y553_K558del | ||
10a | 62/M | ST/13/> 10/HR | Spindle | KIT: p. K558_V559del | Yes/NED/6 |
10b | ST/5/> 10/HR | Spindle | KIT: p. K558_V559del | ||
11a | 70/M | ST/17/> 10/HR | Spindle | KIT: p.M552_V560del | Yes/AWD/38 |
11b | ST/3/> 10/HR | Spindle | KIT: p.M552_V560del |