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Table 3 Comparison between ROC1, P21 and CAIX expression in control group and bladder carcinoma cases

From: ROC-1, P21 and CAIX as markers of tumor aggressiveness in bladder carcinoma in Egyptian patients

VariablesCategorycontrol group (n = 15)Malignant group (n = 80)Test of significancep_value
ROC1
expression
Negative1 (6.66%)8 (10%)FE = 0.161
Positive14 (93.33%)72 (90%)
ROC1 Sub cellular localizationCytoplasmic8 (57.14%)24 (33.3%)×2 = 2.840.09
Nucleocytoplasmic6 (42.86%)48 (66.7%)
ROC1
H-score
Low expression8 (57.1%)37 (51.4%)X2 = 0.160.69
High expression6 (42.9%)35 (48.6%)
P21 expressionNegative5 (33.3%)13 (16.25%)FE = 2.40.1
Positive10 (66.7%)67 (83.75%)
P21 Sub cellular localizationCystoplasmic8 (80%)55 (82.1%)FE = 0.031
Nucleocytoplasmic2 (20%)12 (17.9%)
P21 H-scoreLow expression5 (50%)34 (50.7%)FE = 0.0021
High expression5 (50%)33 (49.3%)
CAIX expressionNegative11 (26.2%)31 (73.8%)x2 = 6.130.01*
Positive4 (7.5%)49 (92.5%)
CAIX Sub cellular localizationCystoplasmic4 (8.3%)44 (91.7%)FE = 0.451
Nucleocytoplasmic0 (0%)5 (100%)
CAIX H-scoreLow expression1 (3.1%)31 (96.9%)FE = 0.221
High expression3 (14.3%)18 (85.7%)
  1. No number, * significant, FE fisher’s exact test