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Table 3 Comparison between ROC1, P21 and CAIX expression in control group and bladder carcinoma cases

From: ROC-1, P21 and CAIX as markers of tumor aggressiveness in bladder carcinoma in Egyptian patients

Variables

Category

control group (n = 15)

Malignant group (n = 80)

Test of significance

p_value

ROC1

expression

Negative

1 (6.66%)

8 (10%)

FE = 0.16

1

Positive

14 (93.33%)

72 (90%)

ROC1 Sub cellular localization

Cytoplasmic

8 (57.14%)

24 (33.3%)

×2 = 2.84

0.09

Nucleocytoplasmic

6 (42.86%)

48 (66.7%)

ROC1

H-score

Low expression

8 (57.1%)

37 (51.4%)

X2 = 0.16

0.69

High expression

6 (42.9%)

35 (48.6%)

P21 expression

Negative

5 (33.3%)

13 (16.25%)

FE = 2.4

0.1

Positive

10 (66.7%)

67 (83.75%)

P21 Sub cellular localization

Cystoplasmic

8 (80%)

55 (82.1%)

FE = 0.03

1

Nucleocytoplasmic

2 (20%)

12 (17.9%)

P21 H-score

Low expression

5 (50%)

34 (50.7%)

FE = 0.002

1

High expression

5 (50%)

33 (49.3%)

CAIX expression

Negative

11 (26.2%)

31 (73.8%)

x2 = 6.13

0.01*

Positive

4 (7.5%)

49 (92.5%)

CAIX Sub cellular localization

Cystoplasmic

4 (8.3%)

44 (91.7%)

FE = 0.45

1

Nucleocytoplasmic

0 (0%)

5 (100%)

CAIX H-score

Low expression

1 (3.1%)

31 (96.9%)

FE = 0.22

1

High expression

3 (14.3%)

18 (85.7%)

  1. No number, * significant, FE fisher’s exact test