ROC-1, P21 and CAIX as markers of tumor aggressiveness in bladder carcinoma in Egyptian patients

Al-Sharaky, Dalia Rifaat; Kandil, Mona Abd El-Halim; Aiad, Hayam Abdel Samie; El-hosary, Enas Megahed; Alagizy, Hagar Abdelmagied; Elshenawy, Mahmoud Abdel-Sattar; El-Rebey, Hala Said

doi:10.1186/s13000-020-00947-7

Diagnostic Pathology

Table 6 Univariate survival analysis for studied bladder carcinoma cases

From: ROC-1, P21 and CAIX as markers of tumor aggressiveness in bladder carcinoma in Egyptian patients

Variable	Overall survival (months)
Variable	Mean survival time	SE	Log rank	P-value
Gender
Male	42.417	2.323	0.009	0.926
Female	45.429	4.508	0.009	0.926
Age (years)
≤ 60	43.120	2.954	0.024	0.877
> 60	42.209	2.979	0.024	0.877
Size of mass
Absent	44.258	3.551	0.0	0.982
Present	42.210	2.472	0.0	0.982
Diagnosis
TCC	42.986	2.139	0.021	0.886
Squamous ca	43.800	8.941	0.021	0.886
Grade
Poorly diff	30.0	0.0	1.726	0.422
Moderate differ.	47.250	10.872
High	42.986	2.139
Bilharsiasis
Absent	44.632	2.654	2.271	0.132
Present	39.438	3.244	2.271	0.132
Necrosis
Absent	43.615	2.475	0.047	0.829
Present	40.857	3.787	0.047	0.829
LVI
Absent	42.828	2.354	0.066	0.798
Present	42.778	4.558	0.066	0.798
PNI
Absent	43.537	2.203	1.211	0.271
Present	37.833	6.263	1.211	0.271
Stroma
Inflammatory	41.769	3.530	0.232	0.630
Desmoplastic	43.252	2.559	0.232	0.630
Tumor stage
T1	44.258	3.551	1.922	0.589
T2	43.129	3.213
T3	39.054	3.823
T4	52.333	11.681
Ms invaion
Absent	44.258	3.551	0.0	0.982
Present	42.210	2.472	0.0	0.982
Node
Absent	41.848	2.322	0.988	0.320
Present	44.322	4.061
Reactivity (ROC-1 Immunohistochemistry)
Negative	59.0	0.0	1.454	0.228
Positive	42.100	2.095	1.454	0.228
Pattern (ROC-1 Immunohistochemistry)
Negative	59.0	0.0	2.415	0.299
Cytoplasmic	40.134	3.038
Nuclear/cytopl	42.940	2.723
H score (ROC-1 Immunohistochemistry)
Low median (< 90)	43.904	2.904	0.044	0.834
High median (> 90)	41.947	2.987	0.044	0.834
IRS (ROC-1 Immunohistochemistry)
Low	43.519	2.454	1.323	0.250
High	40.700	3.950	1.323	0.250
Reactivity (CAIX Immunohistochemstry
Negative	45.948	3.149	1.077	0.299
Positive	40.856	2.703	1.077	0.299
Pattern (CAIX Immunohistochemstry
Negative	45.948	3.149	1.077	0.299
Cytoplasmic	40.856	2.703	1.077	0.299
H score (CAIX Immunohistochemstry
Low median (< 90)	43.342	3.628	3.498	0.061
High median (> 90)	36.500	3.591	3.498	0.061

No comparison analysis was performed for urothelial carcinoma and squamous cell carcinoma grades because the factor variable had only one value
CI Confidence interval

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ISSN: 1746-1596

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