Table 4 Univariate and multivariate analysis of disease-specific survival in 29 mRCC cases with follow-up information
From: Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC
Variable | n | Mean survival in month (95% CI) | Univariate P-value | HR(95% CI) | Multivariate P-value |
|---|---|---|---|---|---|
RSK4 | 0.959 | 0.333 | 0.409 | ||
+ | 22 | 30 | |||
- | 7 | 32 | |||
CD44 | 0.581 | 0.949 | 0.959 | ||
+ | 22 | 36 | |||
- | 7 | 29 | |||
MMP-9 | 0.038 | 0.282 | 0.050 | ||
+ | 26 | 36 | |||
- | 3 | 13 | |||
age | 0.329 | 0.482 | 1.623 | ||
≥ 55 | 9 | 13 | |||
< 55 | 20 | 36 | |||
gender | 0.300 | 0.285 | 2.465 | ||
male | 24 | 30 | |||
female | 5 | 40 | |||
WHO/ISUP nucleolar grade | 0.018 | 0.286 | 0.029 | ||
1~2 | 23 | 36 | |||
3~4 | 6 | 12 | |||
Metastatic sites | 0.529 | 0.729 | 0.187 | ||
bone | 15 | 24 | |||
lung | 4 | 12.5 | |||
brain | 3 | 32 | |||
soft tissue | 6 | 32.5 | |||
others | 1 | 39 |