Fig. 1

Histologic features and special stains of Paget’s cells in primary perianal Paget’s disease. a, b Paget’s cells in primary perianal Paget’s disease are large, hyperchromatic with pale cytoplasm and prominent nucleoli (hematoxylin and eosin; a, × 100; b, × 400). The Paget’s cells in primary perianal Paget’s disease (c, hematoxylin and eosin) are positive for CK7 (d) and GCDFP-15 (e) by immunohistochemistry. f Mucicarmine stain highlights intracellular mucin. Magnifications: c-f, × 200