Automated quantitative analysis of Ki-67 staining and HE images recognition and registration based on whole tissue sections in breast carcinoma

Table 3 Manual labelling of “gold standard” results for Ki-67 positive cells in the human-machine challenge

number	Positive nuclei count	Negative nuclei count	Total number of cells	Ki-67 Index score (%)	Standard score
1	29,961	299,428	329,389	9.10	9 or 10
2	50,073	270,593	320,666	15.62	15 or 16
3	31,119	73,719	104,838	29.68	29 or 30
4	20,272	109,013	129,285	15.68	15 or 16
5	9854	79,026	88,880	11.09	11 or 12
6	11,939	122,641	134,580	8.87	8 or 9
7	9332	100,608	109,940	8.49	8 or 9
8	232,515	86,582	319,097	72.87	72 or 73
9	30,003	270,266	300,266	9.99	9 or 10
10	85,036	69,088	154,124	55.17	55 or 56
Sum	510,104	1,480,964	1,991,068	–
Average	51,010	148,096	199,107	25.62

ISSN: 1746-1596