Table 4 Relationships between BRAF V600E alone or RET fusion alone or BRAF + TERT or BRAF + RAS mutations and clinicopathological features in PTC patients
Characteristics | BRAF V600E | RET Fusion | BRAF + TERT | BRAF + RAS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Positive (N = 119) | Negative (N = 49) | P-value | Positive (N = 13) | Negative (N = 155) | P-value | Positive (N = 10) | Negative (N = 158) | P-value | Positive (N = 7) | Negative (N = 161) | P-value | |
Gender | ||||||||||||
Female | 92 (77.3) | 39 (79.6) | 0.746 | 9 (71.4) | 122 (78.6) | 0.428 | 7 (70.0) | 124 (78.5) | 0.530 | 6 (85.7) | 125 (77.6) | 0.614 |
Male | 27 (22.7) | 10 (20.4) | 4 (28.6) | 33 (21.4) | 3 (30.0) | 34 (21.5) | 1 (14.3) | 36 (22.4) | ||||
Age | ||||||||||||
< 45 | 73 (61.3) | 34 (69.4) | 0.324 | 11 (85.7) | 96 (61.7) | 0.102 | 2 (20.0) | 105 (66.5) | 0.003* | 5 (71.4) | 102 (63.4) | 0.679 |
≥ 45 | 46 (38.7) | 15 (30.6) | 2 (14.3) | 59 (38.3) | 8 (80.0) | 53 (33.5) | 2 (28.6) | 58 (36.6) | ||||
Subtypes | ||||||||||||
conventional PTC | 116 (97.5) | 40 (81.6) | < 0.001* | 11 (85.7) | 145 (93.5) | 0.230 | 10 (100) | 146 (92.4) | 0.366 | 7 (100) | 149 (92.5) | 0.454 |
follicular variant PTC | 3 (2.5) | 9 (18.4) | 2 (14.3) | 10 (6.5) | 0 (0) | 12 (7.6) | 0 (0) | 12 (7.5) | ||||
Lymph node metastasis | ||||||||||||
Yes | 107 (89.9) | 42 (85.7) | 0.434 | 12 (92.9) | 137 (88.3) | 0.668 | 9 (90.0) | 140 (88.6) | 0.893 | 6 (85.7) | 143 (88.8) | 0.800 |
No | 12 (10.1) | 7 (24.3) | 1 (7.1) | 18 (11.7) | 1 (10.0) | 18 (11.4) | 1 (14.3) | 18 (11.2) | ||||
AJCC disease stage | ||||||||||||
I + II | 75 (63.0) | 34 (69.4) | 0.432 | 11 (85.7) | 98 (63.0) | 0.121 | 2 (20.0) | 107 (67.7) | 0.002* | 5 (71.4) | 104 (64.6) | 0.711 |
III + IV | 44 (37.0) | 15 (30.6) | 2 (14.3) | 57 (37.0) | 8 (80.0) | 51 (32.3) | 2 (28.6) | 57 (35.4) | ||||
Lesion number | ||||||||||||
Single lesion | 54 (55.5) | 24 (75.5) | 0.671 | 10 (76.9) | 93 (60.0) | 0.655 | 2 (20.0) | 76 (63.9) | 0.084 | 0 (28.6) | 78 (62.7) | 0.015* |
Multiple lesions | 65 (44.5) | 25 (24.5) | 3 (23.1) | 62 (40.0) | 8 (80.0) | 82 (36.1) | 7 (71.4) | 83 (37.3) | ||||