Fig. 2

Management of brain and rib metastasis treatment. Head MRI (2019/2/11) showed a 13 mm cranial lesion (upper panel: T2-weighted MRI) (a) and bone destruction in the right posterior 12th rib was detected by an CT scan (d and g). After 1 months of EGFR tyrosine kinase inhibitor treatment, a slight enlargement (to 16 cm) of the brain metastasis lesion (b) and bone destruction in 12th rib worsened(e and h). The patient was treated with crizotinib, brain metastatic lesion received a local tomotherpy contemporary but the rib lesion without radiotherapy. Three months after the therapy, imaging examinations revealed obvious decrease in the size of the brain metastases (c). The rib lesion almost disappeared and showed bony restoration (f and 2i)