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Table 1 DNA damage repair genes included in FoundationOne CDx NGS panel

From: High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas

Pathways

NER

MMR

FA

HR

Checkpoint

Others

Genes

ERCC2

MLH1

BRCA2

BRCA1

ATM

POLE

 

ERCC3

MSH2

BRIP1

MRE11A

ATR

MUTYH

 

ERCC4

MSH6

FANCA

NBN

CHEK1

PARP1

 

ERCC5

PMS1

FANCC

RAD50

CHEK2

RECQL4

  

PMS2

PALB2

RAD51

MDC1

 
   

RAD51C

RAD51B

  
   

BLM

RAD51D

  
    

RAD52

  
    

RAD54L

  
  1. Abbreviations: NER nucleotide excision repair, MMR mismatch repair, FA Fanconi Anemia, HR homologous recombination