Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy

Diagnostic Pathology

Table 1 Correlations between clinicopathological characteristics and PD-L1 expression before NAC, after NAC, as well as the change of PD-L1

	Age		FIGO stage		Histological grade		Clinical response		Lymph node metastasis		HPV status
	< 40	≥40	Ib2	IIa2	I-II	III	CR	Non-CR	Yes	No	+	_
PD-L1 before NAC
Low	16	80	68	28	80	16	71	25	9	87	36	3
High	15	31	28	18	35	11	37	9	5	41	75	3
p value (χ2)	0.031 (4.631)		0.235 (1.410)		0.303 (1.060)		0.397 (0.716)		0.780 (0.078)		0.374 (0.791)
PD-L1 after NAC
Low	18	58	52	24	62	14	61	15	5	71	63	4
High	13	53	44	22	53	13	47	19	9	57	48	2
p value (χ2)	0.566 (0.329)		0.824 (0.050)		0.847 (0.037)		0.207 (1.589)		0.159 (1.980)		0.633 (0.228)
PD-L1 change
increase/stable	20	85	73	32	87	18	74	31	12	93	80	3
decrease	11	26	23	14	28	9	34	3	2	35	31	3
p value (χ2)	0.176 (1.829)		0.411 (0.677)		0.338 (0.916)		0.009 (6.890)		0.291 (1.117)		0.246 (1.345)

ISSN: 1746-1596