Fig. 3
The effect of miR-142-5p on isoflurane-induced neurological impairment. a The increasing trend of miR-142-5p expression induced by isoflurane treatment was significantly attenuated by the downregulation of miR-142-5p. b MiR-142-5p downregulation significantly reduced the neurological function score which was increased by isoflurane treatment. c-d MiR-142-5p downregulation significantly alleviated the influence of isoflurane on the latency time of rats during the spatial acquisition training time, but showed no significant influence on the swimming speed. e-f MiR-142-5p downregulation reversed the effects of isoflurane treatment on the escape latency and the time in the original quadrant at the end of learning. *** P < 0.001, compared with control group; #P < 0.05, ###P < 0.001, compared with isoflurane group