Fig. 2

Kaplan-Meier survival plots of overall survival. In the entire cohort (N = 514), the subgroups with more advanced-stage tumors (a), the combined subset of tumoral PD-L1(+)/immune cell PD-L1(−)/CD8^+low tumors (b) exhibit the lowest rates of patient survival within each corresponding analysis based on the Cox proportional hazards model. I, II, III and IV in (A) indicate TNM tumor stage. Tumoral PD-L1(+) (c), FOXP3^+/low (d), and the combined subset of tumoral PD-L1(+)/FOXP3^+/low tumors (e) reveal the lowest rates of patient survival through each corresponding univariate analysis. Corresponding P value, hazard ratio (HR) and 95% confidence interval (CI) in the worst prognostic subset are shown in the bottom left corner of each plot, and P values throughout all subsets, in the bottom right corner of each plot