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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Prognostic perspectives of PD-L1 combined with tumor-infiltrating lymphocytes, Epstein-Barr virus, and microsatellite instability in gastric carcinomas

Fig. 4

Kaplan-Meier plots of overall survival in EBV-positive or MSI-high gastric carcinomas. a-c In EBV-positive gastric carcinomas (N = 32), more advanced-stage tumors (a), tumoral PD-L1(+) (b), and the combined subset of tumoral PD-L1(+)/FOXP3+/low TILs (c) are associated with lower rates of patient survival. I, II, III and IV in (a) indicate TNM tumor stage. d-e In MSI-high gastric carcinomas (N = 53), the combined subsets of tumoral PD-L1(+)/CD8+/low TILs (d) and tumoral PD-L1(+)/immune cell PD-L1(−)/CD8+/low TILs (e) show a worse overall survival rate. Corresponding P value, hazard ratio (HR) and 95% confidence interval (CI) in the worst prognostic subset are shown in the bottom left corner of each plot, and P values throughout all subsets, in the bottom right corner of each plot

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