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Table 1 CK20, AMACR, and p53 staining in Intradepartmental Consensus Urothelial Lesions

From: CK20 versus AMACR and p53 immunostains in evaluation of Urothelial Carcinoma in Situ and Reactive Atypia

  

CK20 Proportion

CK20 Intensity

AMACR Proportion

AMACR Intensity

p53 Patterna

 

N (%)

±

+

0+

1+

2+

±

+

0+

1+

2+

Wild type

Mutant

Equivocal

Reactive

15

13 (87)

1 (7)

1 (7)

13 (87)

1 (7)

1 (7)

15 (100)

0

0

15 (100)

0

0

12 (80)

0

3 (20)

CIS

15

1 (7)

4 (27)

10 (67)

1 (7)

4 (27)

10 (67)

3 (20)

5 (33)

7 (47)

3 (20)

8 (53%)

4 (27)

1 (7)

9 (60)

5 (33)

  1. Abbreviations: CK20 cytokeratin 20, AMACR alpha-methylacyl-CoA racemase;
  2. Staining Proportion: -, negative; ±, patchy; +, diffuse
  3. Staining Intensity: 0+ negative; 1+ weak; 2+ strong
  4. a Please see Methods for description of scoring pattern