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Table 1 Clinicopathologic variables and the expression of FAM83H and ZNF16 in gallbladder carcinomas

From: Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma

CharacteristicsNo.nuclear FAM83Hcytoplasmic FAM83Hnuclear ZNF16cytoplasmic ZNF16
PositivepPositivepPositivepPositivep
Age, years
  <  655523 (42%)0.29615 (27%)0.24130 (55%)0.57316 (29%)0.046
  ≥ 655026 (52%) 19 (38%) 30 (60%) 24 (48%) 
Sex
 Male5526 (47%)0.89619 (35%)0.61931 (56%)0.86622 (40%)0.673
 Female5023 (46%) 15 (30%) 29 (58%) 18 (36%) 
CEA
 Normal8639 (45%)0.56527 (31%)0.64650 (58%)0.66135 (41%)0.243
 Elevated1910 (53%) 7 (37%) 10 (53%) 5 (26%) 
CA19–9
 Normal7130 (42%)0.19023 (32%)0.99736 (51%)0.05425 (35%)0.379
 Elevated3419 (56%) 11 (32%) 24 (71%) 15 (44%) 
TNM stage
 I257 (28%)0.1225 (20%)0.0408 (32%)0.0283 (12%)0.003
 II3719 (51%) 11 (30%) 23 (62%) 20 (54%) 
 III3115 (48%) 10 (32%) 20 (65%) 10 (32%) 
 IV128 (67%) 8 (67%) 9 (75%) 7 (58%) 
T category
 T1267 (27%)0.1015 (19%)0.0718 (31%)0.0143 (12%)<  0.001
 T25026 (52%) 15 (30%) 31 (62%) 27 (54%) 
 T32513 (52%) 11 (44%) 18 (72%) 7 (28%) 
 T443 (75%) 3 (75%) 4 (100%) 3 (75%) 
LN metastasis
 Absence7934 (43%)0.19425 (32%)0.77943 (54%)0.32832 (41%)0.375
 Presence2615 (58%) 9 (35%) 17 (65%) 8 (31%) 
Distant metastasis
 Absence9845 (46%)0.56529 (30%)0.02254 (55%)0.11436 (37%)0.283
 Presence74 (57%) 5 (71%) 6 (86%) 4 (57%) 
Lymphovascular invasion
 Absence9544 (46%)0.82429 (31%)0.21152 (55%)0.12538 (40%)0.215
 Presence105 (50%) 5 (50%) 8 (80%) 2 (20%) 
Histologic type
 Adenocarcinoma NOS10148 (48%)0.57132 (32%)0.34858 (57%)0.48538 (38%)0.435
 Adenosquamous carcinoma31 (33%) 2 (67%) 2 (67%) 2 (67%) 
 Squamous cell carcinoma NOS10 (0%) 0 (0%) 0 (0%) 0 (0%) 
Histologic grade
 Low4315 (35%)0.0447 (16%)0.00315 (35%)<  0.00112 (28%)0.073
 High6234 (55%) 27 (44%) 45 (73%) 28 (45%) 
cytoplasmic ZNF16
 Negative6526 (40%)0.08125 (23%)0.00928 (43%)<  0.001  
 Positive4023 (58%) 19 (48%) 32 (80%)   
nuclear ZNF16
 Negative4513 (29%)0.0029 (20%)0.019    
 Positive6036 (60%) 25 (42%)     
cytoplasmic FAM83H
 Negative7124 (34%)<  0.001      
 Positive3425 (74%)       
  1. Abbreviations: CEA carcinoembryonic antigen, CA19–9 carbohydrate antigen 19–9, LN lymph node, NOS not otherwise specified