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Table 5 Clinicopathologic variables and co-expression patterns of nuclear FAM83H and nuclear ZNF16 in gallbladder carcinomas

From: Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma

CharacteristicsNo.nFAM83H/nZNF16 co-expression
−/−−/+, +/−, or +/+p
Age, years
  <  655520 (36%)35 (64%)0.169
  ≥ 655012 (24%)38 (76%) 
Sex
 Male5516 (29%)39 (71%)0.746
 Female5016 (32%)34 (68%) 
CEA
 Normal8625 (29%)61 (71%)0.505
 Elevated197 (37%)12 (63%) 
CA19–9
 Normal7125 (35%)46 (65%)0.128
 Elevated347 (21%)27 (79%) 
TNM stage
 I2514 (56%)11 (44%)0.016
 II379 (24%)28 (76%) 
 III317 (23%)24 (77%) 
 IV122 (17%)10 (83%) 
T category
 T12615 (58%)11 (42%)0.006
 T25012 (24%)38 (76%) 
 T3254 (16%)21 (84%) 
 T441 (25%)3 (75%) 
LN metastasis
 Absence7927 (34%)52 (66%)0.151
 Presence265 (19%)21 (81%) 
Distant metastasis
 Absence9831 (32%)67 (68%)0.335
 Presence71 (14%)6 (86%) 
Lymphovascular invasion
 Absence9531 (33%)64 (67%)0.139
 Presence101 (10%)9 (90%) 
Histologic type
 Adenocarcinoma NOS10131 (31%)70 (69%)0.165
 Adenosquamous carcinoma30 (0%)3 (100%) 
 Squamous cell carcinoma NOS11 (100%)0 (0%) 
Histologic grade
 Low4321 (49%)22 (51%)<  0.001
 High6211 (18%)51 (82%) 
  1. Abbreviations: nFAM83H nuclear expression of FAM83H, nZNF16 nuclear expression of ZNF16, CEA carcinoembryonic antigen, CA19–9 carbohydrate antigen 19–9, LN lymph node, NOS not otherwise specified