Table 5 Clinicopathologic variables and co-expression patterns of nuclear FAM83H and nuclear ZNF16 in gallbladder carcinomas
Characteristics | No. | nFAM83H/nZNF16 co-expression | ||
|---|---|---|---|---|
−/− | −/+, +/−, or +/+ | p | ||
Age, years | ||||
< 65 | 55 | 20 (36%) | 35 (64%) | 0.169 |
≥ 65 | 50 | 12 (24%) | 38 (76%) | |
Sex | ||||
Male | 55 | 16 (29%) | 39 (71%) | 0.746 |
Female | 50 | 16 (32%) | 34 (68%) | |
CEA | ||||
Normal | 86 | 25 (29%) | 61 (71%) | 0.505 |
Elevated | 19 | 7 (37%) | 12 (63%) | |
CA19–9 | ||||
Normal | 71 | 25 (35%) | 46 (65%) | 0.128 |
Elevated | 34 | 7 (21%) | 27 (79%) | |
TNM stage | ||||
I | 25 | 14 (56%) | 11 (44%) | 0.016 |
II | 37 | 9 (24%) | 28 (76%) | |
III | 31 | 7 (23%) | 24 (77%) | |
IV | 12 | 2 (17%) | 10 (83%) | |
T category | ||||
T1 | 26 | 15 (58%) | 11 (42%) | 0.006 |
T2 | 50 | 12 (24%) | 38 (76%) | |
T3 | 25 | 4 (16%) | 21 (84%) | |
T4 | 4 | 1 (25%) | 3 (75%) | |
LN metastasis | ||||
Absence | 79 | 27 (34%) | 52 (66%) | 0.151 |
Presence | 26 | 5 (19%) | 21 (81%) | |
Distant metastasis | ||||
Absence | 98 | 31 (32%) | 67 (68%) | 0.335 |
Presence | 7 | 1 (14%) | 6 (86%) | |
Lymphovascular invasion | ||||
Absence | 95 | 31 (33%) | 64 (67%) | 0.139 |
Presence | 10 | 1 (10%) | 9 (90%) | |
Histologic type | ||||
Adenocarcinoma NOS | 101 | 31 (31%) | 70 (69%) | 0.165 |
Adenosquamous carcinoma | 3 | 0 (0%) | 3 (100%) | |
Squamous cell carcinoma NOS | 1 | 1 (100%) | 0 (0%) | |
Histologic grade | ||||
Low | 43 | 21 (49%) | 22 (51%) | < 0.001 |
High | 62 | 11 (18%) | 51 (82%) | |