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Table 6 Univariate and multivariate Cox regression analysis for overall survival and relapse-free survival according to the co-expression patterns of nuclear FAM83H and nuclear ZNF16 in gallbladder carcinomas

From: Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma

CharacteristicsOSpRFSp
HR (95% CI)HR (95% CI)
Univariate analysis
 nFAM83H/nZNF16, +/−, −/+, or +/+ (vs. −/−)5.463 (2.598–11.487)<  0.0014.796 (2.367–9.717)<  0.001
Multivariate analysis
 Age, y ≥ 65 (vs. < 65)3.383 (1.989–5.755)<  0.0013.249 (1.925–5.484)<  0.001
 TNM stage
  I1<  0.0011<  0.001
  II1.897 (0.830–4.257)0.1302.019 (0.895–4.558)0.091
  III5.318 (2.307–12.257)<  0.0014.939 (2.219–11.459)<  0.001
  IV25.409 (8.833–73.088)<  0.00122.922 (1.988–65.772)< 0.001
 Histologic type
  adenocarcinoma NOS10.00810.010
  adenosquamous carcinoma0.726 (0.214–2.458)0.6070.644 (0.190–2.180)0.480
  squamous cell carcinoma NOS35.714 (3.628–351.524)0.00229.708 (3.079–286.603)0.003
 nFAM83H/nZNF16, +/−, −/+, or +/+ (vs. −/−)4.808 (2.143–10.791)<  0.0014.204 (1.958–9.029)<  0.001
  1. Abbreviations: OS overall survival, RFS relapse-free survival, HR hazard ratio, 95% CI 95% confidence interval; nFAM83H/nZNF16, co-expression patterns of nuclear FAM83H, and nuclear ZNF16. Variables considered in the multivariate analysis were age, preoperative serum level of CA19–9, tumor stage, T category of tumor stage, lymph node metastasis, distant metastasis, lymphovascular invasion, histologic type, histologic grade, and the co-expression patterns of nuclear FAM83H and nuclear ZNF16