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Table 6 Univariate and multivariate Cox regression analysis for overall survival and relapse-free survival according to the co-expression patterns of nuclear FAM83H and nuclear ZNF16 in gallbladder carcinomas

From: Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma

Characteristics

OS

p

RFS

p

HR (95% CI)

HR (95% CI)

Univariate analysis

 nFAM83H/nZNF16, +/−, −/+, or +/+ (vs. −/−)

5.463 (2.598–11.487)

<  0.001

4.796 (2.367–9.717)

<  0.001

Multivariate analysis

 Age, y ≥ 65 (vs. < 65)

3.383 (1.989–5.755)

<  0.001

3.249 (1.925–5.484)

<  0.001

 TNM stage

  I

1

<  0.001

1

<  0.001

  II

1.897 (0.830–4.257)

0.130

2.019 (0.895–4.558)

0.091

  III

5.318 (2.307–12.257)

<  0.001

4.939 (2.219–11.459)

<  0.001

  IV

25.409 (8.833–73.088)

<  0.001

22.922 (1.988–65.772)

< 0.001

 Histologic type

  adenocarcinoma NOS

1

0.008

1

0.010

  adenosquamous carcinoma

0.726 (0.214–2.458)

0.607

0.644 (0.190–2.180)

0.480

  squamous cell carcinoma NOS

35.714 (3.628–351.524)

0.002

29.708 (3.079–286.603)

0.003

 nFAM83H/nZNF16, +/−, −/+, or +/+ (vs. −/−)

4.808 (2.143–10.791)

<  0.001

4.204 (1.958–9.029)

<  0.001

  1. Abbreviations: OS overall survival, RFS relapse-free survival, HR hazard ratio, 95% CI 95% confidence interval; nFAM83H/nZNF16, co-expression patterns of nuclear FAM83H, and nuclear ZNF16. Variables considered in the multivariate analysis were age, preoperative serum level of CA19–9, tumor stage, T category of tumor stage, lymph node metastasis, distant metastasis, lymphovascular invasion, histologic type, histologic grade, and the co-expression patterns of nuclear FAM83H and nuclear ZNF16