Fig. 2

a This photomicrograph of the previously resected pituitary lesion shows monotonous neoplastic cells (Original magnification × 200). b The neoplastic cells show diffuse expression of the nuclear neuroendocrine marker insulinoma associated protein (INSM1) (Original magnification × 200). c The liver shows nodules of tumor cells with moderate amounts of cytoplasm, clumped chromatin and variably prominent nucleoli (Original magnification × 200). Inset: Ki-67 shows an elevated proliferative rate of more than 10% (Original magnification × 200). d The neuroendocrine marker, INSM1 was diffusely positive in the tumor cells (original magnification × 200). e The transcription factor, T-PIT is diffusely positive confirming pituitary origin of the tumor cells (Original magnification × 100). f OSCAR cytokeratin also highlighted the tumor cells (Original magnification × 100)