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Fig. 1 | Diagnostic Pathology

Fig. 1

From: The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

Fig. 1

– case 1 a. Immunohistochemical confirmation of acinar cell component. a HE acinar differentiating within metastatic teratomatous type II TGCT, immunolabeling with antibodies against trypsin, chymotrypsin, lipase and BCL10; electron microscopy of zymogen granules. b. Molecular genetic analysis of the ACC within the teratomatous type II TGCT and a control ACC. Arrow pointing to chromosome 12p showing probable amplification in the primary TGCT, and evident amplification in the teratoma ACC compared to control ACC. c. Cytogenetic analysis of the primary teratomatous type II TGCT and the ACC. FISH results for centromere (CEN12, A, D, G) and telomere (TEL12, B, E, H) regions on chromosome 12 and control probes (CEN1 and CEN6, C, F, I)

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