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Fig. 2 | Diagnostic Pathology

Fig. 2

From: The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

Fig. 2

– case 2 a. (Immune) histochemical similarities of the peritoneal metastasis and the dysplastic intestinal component of the teratomatous type II TGCT. HE stained slides at different magnifications and immunolabeling with antibodies against CK7 and CK20. b. Molecular genetic analysis of the peritoneal metastasis and the dysplastic intestinal component of the teratomatous type II TGCT by SNP array. Chromosome 12 is shown in detail which shows a different pattern in gains and losses of both tumors: high gains of the entire 12p and a part of 12q and CN-LOH of 12q in the teratomatous type II TGCT and multiple partial high gains of chromosome 12p and a partial high gain of 12q and multiple gains of chromosome 12q in the metastasic adenocarcinoma. c. Molecular genetic analysis of the peritoneal metastasis and the dysplastic intestinal component of the teratomatous type II TGCT by NGS. The peritoneal metastasis showed a mutation in KRAS and GNAS while the primary teratomatous type II TGCT showed no mutations in the genes investigated in this panel

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