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Table 2 Histopathology of COVID-19

From: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) – anatomic pathology perspective on current knowledge

Authors PMID Specimen type No. of cases Main findings DAD Thrombi
Xu et al. [38] 32,085,846 Post-mortem biopsies of lung, liver, and heart 1 DAD Yes None mentioned
Tian et al. [39] 32,114,094 Lobectomies 2 DADand mononuclear inflammatory cells Yes (early DAD pattern in 1 of 2) None mentioned
Barton et al. [40] 32,275,742 Complete autopsies 2 DAD and chronic airway inflammation Yes (1 case) Few (lung, case 1)
Karami et al. [41] 32,283,217 Autopsy of the lungs 1 Hyaline membranes and viral cytopathic effect Yes (hyaline membrane noted) None mentioned
Tian et al. [42] 32,291,399 Post-mortem biopsies of lung, liver, and heart 4 DAD Yes None mentioned
Magro et al. [43] 32,299,776 Limited autopsies (2) and skin biopsies (3) 5 “Hemorrhagic pneumonitis” (lung), and “thrombogenic vasculopathy” (skin) Yes (hyaline membranes in 1 of 2 cases in which lungs were examined) Yes (skin)
Barnes et al. [44] 32,302,401 Autopsies (brief mention) 3 “Neutrophil extracellular traps” Not mentioned None mentioned
Varga et al. [45] 32,325,026 Autopsies (2) and small intestine resection (1) 3 “Endothelitis”, DAD, and viral inclusions in the endothelial cells of kidney Yes “Only scattered fibrin thrombi”
Konopka et al. [46] 32,360,729 Autopsy 1 “Fibrinous pneumonia” Yes “Rare fibrin thrombi were also identified within small vessels and a small muscular pulmonary artery”
Menter et al. [27] 32,364,264 Autopsy 21 DAD (exudative in 16, proliferative in 8); Superimposed bronchopneumonia in 10/21 Yes Pulmonary embolism in 4/21; microthrombi of alveolar capillaries in 5/11
Wichmann et al. [47] 32,374,815 Complete autopsies 12 DAD in 8/12; “focal bronchopneumonia” (no DAD) in 4/12 Yes “Massive pulmonary embolism” (4/12); deep vein thrombosis in 3; fresh thrombosis in prostatic venous plexus (6/9 men)
Lax et al. [48] 32,422,076 Autopsies 11 DAD in 11 /11; bronchopneumonia (6/11); Fibrous adhesions (7/11) Yes Thrombosis of small and mid-sized pulmonary arteries (11/11)
Yan et al. [49] 32,422,081 Complete autopsy 1 DAD Yes Pulmonary infarction
Buja et al. [50] 32,434,133 Complete autopsies 3 DAD Yes Pulmonary embolism in 1/3
Martinez et al. [51] 32,437,316 Complete autopsies 8 DAD Yes Fibrinous thrombi in 1/8
Schaller et al. [52] 32,437,497 Complete autopsies 10 DAD Yes ____
Duarte-Neto et al. [53] 32,443,177 Post-mortem “biopsies” 10 DAD Yes Fibrinous thrombi in 8/10; small thrombi in kidneys (glomeruli) and other organs
Sekulic et al. [54] 32,451,533 Complete (1) and partial(1) autopsy 2 DAD Yes _______
Aguiar et al. [55] 32,458,044 Complete autopsy 1 DAD, superimposed pneumonia Yes _______
Schaefer et al. [56] 32,561,849 Autopsies 7 Acute DAD (2/7), organizing DAD (5/7) Yes Pulmonary thromboembolism (5/7)
Beigmohammadi et al. [57] 32,552,178 Post-mortem biopsies from Lung, Heart and Liver 7 DAD (5/7), Acute pneumonia (2/7) Yes None mentioned
Konopka et al. [58] 32,542,743 Limited autopsies 8 DAD (8/8) Yes Fibrin thrombi (5/8)
Escher et al. [59] 32,529,795 Endomyocardial biopsy 5 Myocardial necrosis, small arterial obliteration Not applicable None mentioned
  1. Abbreviation: DAD Diffuse alveolar damage