Fig. 5From: Cutaneous T-cell lymphomas with pathogenic somatic mutations and absence of detectable clonal T-cell receptor gene rearrangement: two case reportsCandidate mutations in patient 1. Top: Structure of PI3K-delta protein with functional domains and point mutation at position 1021 located in the catalytic domain. p85Bā=āp85 binding domain, RBDā=āras binding domain, C2ā=āC2 domain present in class I beta and delta PI3Ks, PI3Kaā=āaccessory domain, PI3Kcā=ācatalytic domain. Middle: Structure of TERT gene and upstream regulatory region showing two point mutations identified in the TERT promoter. Red arrowā=ātranscription start site, ATGā=ācoding sequence start site, ETSā=āETS family transcription factor binding sites. Bottom: Candidate pathogenic mutations identified via targeted sequencing analysis of case 1 biopsy specimen by Heme-STAMP. Filtered depthā=āread depth of the variant alleleBack to article page