Fig. 9From: Cutaneous T-cell lymphomas with pathogenic somatic mutations and absence of detectable clonal T-cell receptor gene rearrangement: two case reportsCandidate pathogenic mutation in patient 2. Top: Structure of p53 protein with binding domains and frameshift mutation at position 343 located in the oligomerization domain. TADā=āTransactivation domain (green), PRDā=āproline rich domain (yellow), ODā=āoligomerization domain (blue). Bottom: Candidate pathogenic mutation identified via targeted sequencing analysis of case 2 biopsy specimen by Heme-STAMP. Filtered depthā=āread depth of the variant alleleBack to article page