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Table 2 Function of partner genes related to GREB1 rearrangement

From: Recurrent uterine tumors resembling ovarian sex-cord tumors with the growth regulation by estrogen in breast cancer 1-nuclear receptor coactivator 2 fusion gene: a case report and literature review

Gene Encoded protein Basic function
CTNNB1 β-Catenin Crucial transcriptional factor in Wingless-Int (Wnt)/β-catenin signaling pathway; transcriptional coactivator for T-cell factor/lymphoid enhancer factor (TCF), and with its transactivation domain, activates transcription initiation, histone methyltransferases, chromatin modification, and transcription facilitation
NCOA1–3 Nuclear Receptor Coactivator 1–3 Transcription factors: coactivate nuclear hormone receptors and mediate steroid/sex-hormone receptor pathways
NR4A3 Nuclear Receptor Subfamily 4 Group A Member 3 Transcription factor: transcriptional activator of the steroid/thyroid hormone nuclear receptor family, with a role in regulating proliferation, survival, and differentiation
SS18 SS18 (or SSXT) Transcription factor: transcriptional coactivator and a component of the SWI/SNF chromatin-remodeling complex