Table 2 Function of partner genes related to GREB1 rearrangement
Gene | Encoded protein | Basic function |
|---|---|---|
CTNNB1 | β-Catenin | Crucial transcriptional factor in Wingless-Int (Wnt)/β-catenin signaling pathway; transcriptional coactivator for T-cell factor/lymphoid enhancer factor (TCF), and with its transactivation domain, activates transcription initiation, histone methyltransferases, chromatin modification, and transcription facilitation |
NCOA1–3 | Nuclear Receptor Coactivator 1–3 | Transcription factors: coactivate nuclear hormone receptors and mediate steroid/sex-hormone receptor pathways |
NR4A3 | Nuclear Receptor Subfamily 4 Group A Member 3 | Transcription factor: transcriptional activator of the steroid/thyroid hormone nuclear receptor family, with a role in regulating proliferation, survival, and differentiation |
SS18 | SS18 (or SSXT) | Transcription factor: transcriptional coactivator and a component of the SWI/SNF chromatin-remodeling complex |