Fig. 3
From: Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma
Molecular analysis of the representative case shown in Fig. 2. a In the CRA sample, a TP53 deletion [c.529_546del18: deletion of codon 177_182 in exon 5, which is indicated between two arrowheads in the (b) normal sample] was seen; c-h DNA methylation analysis. c LOX, d MINT31 and e RUNX3 were not hypermethylated. In the second panel, hypermethylation was seen only for (f) ELMO1 and not (g) THBD (h) NEUROG1 or the MLH-1 promoter (not shown), indicating that CRA can be classified as a low-methylated epigenotype