Table 2 Immunohistochemical findings for crawling-type adenocarcinomas (CRAs) and conventional differentiated adenocarcinomas (CDAs)
From: Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma
CRA (%) | CDA (%) | P-value | |
|---|---|---|---|
Total | 51 (100.0) | 126 (100.0) | |
Mucin phenotype | 0.59 | ||
Gastric type | 19 (37.3) | 35 (27.8) | |
Intestinal type | 12 (23.5) | 39 (31.0) | |
Mixed type | 18 (35.3) | 48 (38.1) | |
Null type (unclassified type) | 2 (3.9) | 4 (3.2) | |
CDX-2 | 0.26 | ||
Positive | 41 (80.4) | 91 (72.2) | |
Negative | 10 (19.6) | 35 (27.8) | |
p53 | 0.422 | ||
Positive | 5 (9.8) | 18 (14.3) | |
Negative | 46 (90.2) | 108 (85.7) | |
β-catenin (nuclear accumulation) | < 0.01 | ||
Positive | 1 (2.0) | 38 (30.2) | |
Negative | 50 (98.0) | 88 (69.8) | |
MLH-1 | 0.04 | ||
Retained | 49 (96.1) | 107 (84.9) | |
Loss of expression | 2 (3.9) | 19 (15.1) |