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Table 4 TP53 mutations and p53 overexpression in crawling-type adenocarcinomas and conventional differentiated adenocarcinomas

From: Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma

 

CRA (%)

CDA (%)

TP53 mutation

p53 overexpression

TP53 mutation

p53 overexpression

Total cases

51

51

126

126

 Cases

19 (37.3)

5 (9.8)

10 (7.9)

18 (14.3)

 Number of TP53 mutation loci

29 (56.9)

10 (7.9)

Type of TP53 mutation

Exon 5

  c.427G > A (p.Val143Met)

1

0

0

0

  c.440 T > A (p.Val147Asp)

1

1

0

0

  c.443A > G (p.Asp148Gly)

1

0

0

0

  c.446C > T (p.Ser149Phe)

1

0

0

0

  c.459C > T (p.Pro153Pro)

1

1

0

0

  c.476C > T (p.Ala159Val)

1

0

0

0

  c.493C > T (p.Gln165Ter)

1

1

0

0

  c.507G > T (p.Met169Ile)

1

0

0

0

  c.509C > T (p.Thr170Met)

1

0

0

0

  c.529_546del18 (p.Pro177_Cys182del)

10

0

0

0

Exon 6

    

  c.566C > T (p.Ala189Val)

0

0

1

0

  c.586_624del39 (p.Arg196_Asp208del)

0

0

1

1

Exon 7

  c.722C > T (p.Ser241Phe)

0

0

1

1

  c.742C > T (p.Arg248Trp)

2

1

0

0

  c.743G > A (p.Arg248Gln)

0

0

2

2

  c.776A > G (p.Asp259Gly)

1

0

0

0

Exon 8

  c.817C > T (p.Arg273Cys)

1

0

1

1

  c.818G > A (p.Arg273His)

4

1

1

1

  c.817_818delinsTA (p.Arg273Try)

1

0

0

0

  c.839_840delinsCG (p.Arg280Thr)

1

0

0

0

  c.844C > T (p.Arg282Trp)

0

0

1

1

  c.847_897del51 (p.Arg283_Leu299del)

0

0

1

1

  c.853G > A (p.Glu285Lys)

0

0

1

1

  1. CRA crawling-type adenocarcinoma; CDA conventional-type adenocarcinoma