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Table 4 TP53 mutations and p53 overexpression in crawling-type adenocarcinomas and conventional differentiated adenocarcinomas

From: Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma

  CRA (%) CDA (%)
TP53 mutation p53 overexpression TP53 mutation p53 overexpression
Total cases 51 51 126 126
 Cases 19 (37.3) 5 (9.8) 10 (7.9) 18 (14.3)
 Number of TP53 mutation loci 29 (56.9) 10 (7.9)
Type of TP53 mutation
Exon 5
  c.427G > A (p.Val143Met) 1 0 0 0
  c.440 T > A (p.Val147Asp) 1 1 0 0
  c.443A > G (p.Asp148Gly) 1 0 0 0
  c.446C > T (p.Ser149Phe) 1 0 0 0
  c.459C > T (p.Pro153Pro) 1 1 0 0
  c.476C > T (p.Ala159Val) 1 0 0 0
  c.493C > T (p.Gln165Ter) 1 1 0 0
  c.507G > T (p.Met169Ile) 1 0 0 0
  c.509C > T (p.Thr170Met) 1 0 0 0
  c.529_546del18 (p.Pro177_Cys182del) 10 0 0 0
Exon 6     
  c.566C > T (p.Ala189Val) 0 0 1 0
  c.586_624del39 (p.Arg196_Asp208del) 0 0 1 1
Exon 7
  c.722C > T (p.Ser241Phe) 0 0 1 1
  c.742C > T (p.Arg248Trp) 2 1 0 0
  c.743G > A (p.Arg248Gln) 0 0 2 2
  c.776A > G (p.Asp259Gly) 1 0 0 0
Exon 8
  c.817C > T (p.Arg273Cys) 1 0 1 1
  c.818G > A (p.Arg273His) 4 1 1 1
  c.817_818delinsTA (p.Arg273Try) 1 0 0 0
  c.839_840delinsCG (p.Arg280Thr) 1 0 0 0
  c.844C > T (p.Arg282Trp) 0 0 1 1
  c.847_897del51 (p.Arg283_Leu299del) 0 0 1 1
  c.853G > A (p.Glu285Lys) 0 0 1 1
  1. CRA crawling-type adenocarcinoma; CDA conventional-type adenocarcinoma