From: Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma
CRA (%) | CDA (%) | |||
---|---|---|---|---|
TP53 mutation | p53 overexpression | TP53 mutation | p53 overexpression | |
Total cases | 51 | 51 | 126 | 126 |
Cases | 19 (37.3) | 5 (9.8) | 10 (7.9) | 18 (14.3) |
Number of TP53 mutation loci | 29 (56.9) | – | 10 (7.9) | – |
Type of TP53 mutation | ||||
Exon 5 | ||||
c.427G > A (p.Val143Met) | 1 | 0 | 0 | 0 |
c.440 T > A (p.Val147Asp) | 1 | 1 | 0 | 0 |
c.443A > G (p.Asp148Gly) | 1 | 0 | 0 | 0 |
c.446C > T (p.Ser149Phe) | 1 | 0 | 0 | 0 |
c.459C > T (p.Pro153Pro) | 1 | 1 | 0 | 0 |
c.476C > T (p.Ala159Val) | 1 | 0 | 0 | 0 |
c.493C > T (p.Gln165Ter) | 1 | 1 | 0 | 0 |
c.507G > T (p.Met169Ile) | 1 | 0 | 0 | 0 |
c.509C > T (p.Thr170Met) | 1 | 0 | 0 | 0 |
c.529_546del18 (p.Pro177_Cys182del) | 10 | 0 | 0 | 0 |
Exon 6 | ||||
c.566C > T (p.Ala189Val) | 0 | 0 | 1 | 0 |
c.586_624del39 (p.Arg196_Asp208del) | 0 | 0 | 1 | 1 |
Exon 7 | ||||
c.722C > T (p.Ser241Phe) | 0 | 0 | 1 | 1 |
c.742C > T (p.Arg248Trp) | 2 | 1 | 0 | 0 |
c.743G > A (p.Arg248Gln) | 0 | 0 | 2 | 2 |
c.776A > G (p.Asp259Gly) | 1 | 0 | 0 | 0 |
Exon 8 | ||||
c.817C > T (p.Arg273Cys) | 1 | 0 | 1 | 1 |
c.818G > A (p.Arg273His) | 4 | 1 | 1 | 1 |
c.817_818delinsTA (p.Arg273Try) | 1 | 0 | 0 | 0 |
c.839_840delinsCG (p.Arg280Thr) | 1 | 0 | 0 | 0 |
c.844C > T (p.Arg282Trp) | 0 | 0 | 1 | 1 |
c.847_897del51 (p.Arg283_Leu299del) | 0 | 0 | 1 | 1 |
c.853G > A (p.Glu285Lys) | 0 | 0 | 1 | 1 |