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Table 2 CgA, Syn and Ki-67 index variation between primary and metastatic sites

From: Clinicopathological heterogeneity between primary and metastatic sites of gastroenteropancreatic neuroendocrine neoplasm

Patient #

Primary tumor site Site1#

Metastatic tumor site Site2#

aCgA variability

aSyn variability

Ki-67 index(%)

Survival time

WHO class changes

Site1# Site2#

Site1# Site2#

Site1# Site2#

1

pancreas

liver

III

III

III

III

1

1

57

–

2

pancreas

liver

III

III

III

III

10

10

75

–

3

pancreas

abdominal wall

I

II

II

I

40

80

83

NEC → NEC

4

pancreas

liver

III

III

III

III

2

/

23

–

5

pancreas

mesentery

III

II

III

III

10

5

12

NET G2 → NET G2

6

pancreas

liver

II

III

III

III

80

60

3

NEC → NEC

7

pancreas

liver

I

I

II

II

30

25

4

NET G3 → NET G3

8

pancreas

liver

III

II

III

III

2

2

1

–

9

pancreas

liver

III

III

III

III

10

10

7

–

10

pancreas

liver

III

III

III

III

40

40

0

–

11

pancreas

liver

III

/

III

III

5

/

3

–

12

pancreas

lymph node

/

/

III

III

30

30

19

–

13

pancreas

liver

I

II

III

III

15

15

27

–

14

pancreas

pelvic cavity

I

II

III

III

10

5

70

NET G2 → NET G2

15

rectum

liver

/

/

III

III

10

10

97

–

16

rectum

liver

III

III

III

III

2

5

27

NET G1 → NET G2

17

rectum

liver

II

I

III

III

2

25

3

NET G1 → NET G3

18

rectum

lymph node

III

I

III

III

60

80

48

NEC → NEC

19

rectum

lymph node

III

II

III

III

60

80

12

NEC → NEC

20

rectum

Liver

I

I

I

III

95

90

20

NEC → NEC

21

rectum

lymph node

I

I

I

III

95

90

20

NEC → NEC

22

stomach

liver

I

I

III

III

70

70

8

–

23

stomach

iliac fossa

III

II

III

III

35

30

16

NEC → NEC

24

stomach

lymph node

I

I

III

III

/

80

15

–

25

stomach

lung

I

II

III

III

70

70

15

–

26

stomach

liver

I

I

II

III

80

50

1

NEC → NEC

27

stomach

liver

III

II

III

III

80

50

36

NEC → NEC

28

duodenum

liver

III

III

III

III

5

2

5

NET G2 → NET G1

29

duodenum

liver

II

II

III

III

5

5

11

–

30

duodenum

adrenal gland

II

II

III

III

20

35

29

NEC → NEC

31

colon

mesentery

II

II

III

III

60

/

55

–

32

unknown

liver

/

/

III

III

80

60

5

NEC → NEC

33

unknown

liver

II

III

III

III

80

90

1

NEC → NEC

34

unknown

peritoneal

II

II

II

II

30

30

21

–

35

unknown

rectum

III

III

III

III

1

2

61

NET G1 → NET G1

  1. Abbreviations: CgA chromogranin, Syn synaptophysin, NEC neuroendocrine carcinoma; aCgA and Syn graded according to the percent of positive cells as follows: I: < 5%, II: 5–50%, and III: > 50%
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Diagnostic Pathology

ISSN: 1746-1596

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