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Table 2 CgA, Syn and Ki-67 index variation between primary and metastatic sites

From: Clinicopathological heterogeneity between primary and metastatic sites of gastroenteropancreatic neuroendocrine neoplasm

Patient # Primary tumor site Site1# Metastatic tumor site Site2# aCgA variability aSyn variability Ki-67 index(%) Survival time WHO class changes
Site1# Site2# Site1# Site2# Site1# Site2#
1 pancreas liver III III III III 1 1 57
2 pancreas liver III III III III 10 10 75
3 pancreas abdominal wall I II II I 40 80 83 NEC → NEC
4 pancreas liver III III III III 2 / 23
5 pancreas mesentery III II III III 10 5 12 NET G2 → NET G2
6 pancreas liver II III III III 80 60 3 NEC → NEC
7 pancreas liver I I II II 30 25 4 NET G3 → NET G3
8 pancreas liver III II III III 2 2 1
9 pancreas liver III III III III 10 10 7
10 pancreas liver III III III III 40 40 0
11 pancreas liver III / III III 5 / 3
12 pancreas lymph node / / III III 30 30 19
13 pancreas liver I II III III 15 15 27
14 pancreas pelvic cavity I II III III 10 5 70 NET G2 → NET G2
15 rectum liver / / III III 10 10 97
16 rectum liver III III III III 2 5 27 NET G1 → NET G2
17 rectum liver II I III III 2 25 3 NET G1 → NET G3
18 rectum lymph node III I III III 60 80 48 NEC → NEC
19 rectum lymph node III II III III 60 80 12 NEC → NEC
20 rectum Liver I I I III 95 90 20 NEC → NEC
21 rectum lymph node I I I III 95 90 20 NEC → NEC
22 stomach liver I I III III 70 70 8
23 stomach iliac fossa III II III III 35 30 16 NEC → NEC
24 stomach lymph node I I III III / 80 15
25 stomach lung I II III III 70 70 15
26 stomach liver I I II III 80 50 1 NEC → NEC
27 stomach liver III II III III 80 50 36 NEC → NEC
28 duodenum liver III III III III 5 2 5 NET G2 → NET G1
29 duodenum liver II II III III 5 5 11
30 duodenum adrenal gland II II III III 20 35 29 NEC → NEC
31 colon mesentery II II III III 60 / 55
32 unknown liver / / III III 80 60 5 NEC → NEC
33 unknown liver II III III III 80 90 1 NEC → NEC
34 unknown peritoneal II II II II 30 30 21
35 unknown rectum III III III III 1 2 61 NET G1 → NET G1
  1. Abbreviations: CgA chromogranin, Syn synaptophysin, NEC neuroendocrine carcinoma; aCgA and Syn graded according to the percent of positive cells as follows: I: < 5%, II: 5–50%, and III: > 50%