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Table 1 Immunophenotypes of CIRC tumor and small cell carcinoma of this case

From: Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

Antibody Immunophenotype
CIRC tumor Small cell carcinoma
Primary tumor Relapsed tumor
Epithelial markers
 CK7 +
 CK8 + + ±
 CK18 + + ±(weakly)
 CAM5.2 + + ±
 AE1/AE3 + + ±
 EMA + + +
 34βE12
 PSA
 NKX3.1
 P504S
 pCEA
 CK5/6
 CK20
 TTF-1 ±(weakly)
 Napsin A
 p63
 p40
Neuroendocrine cell markers
 NSE +
 Chromogranin A ±
 Synaptophysin +
 CD56 +
Lymphoid markers
 CD3
 CD4
 CD5
 CD8
 CD20
 CD30 (Ki-1)
 CD45 (LCA)
 CD45RO (UCHL-1)
 CD79a
 PAX5
 EBER-1*
FRC markers
 Tenascin-C
 Prolyl 3-hydroxylase 1
 l-caldesmon + +
 Prolyl 4-hydroxylase 1 + +
 Lysyl hydroxylase 3 + +
 Transglutaminase II + +
 α-SMA
FDC markers
 CD23
 D2–40
 Clusterin
 CNA.42
 NGFR, low affinity
 CD21
 CD35
Histiocytic/dendritic cell markers
 CD1a
 CD11c
 Langerin
 DC-SIGN
 DC-LAMP
 CD83
 DEC205
 S-100
 CD68
 Fascin + +
 Factor XIIIa
Others
 Melan A
 HMB45
 Desmin
 Vimentin + +
 CD34
 CD117
 ALK
 EGFR <  10% 20%
 p53 95% 80%
 Ki-67 (hot spot) >  75% 15% <  50%
  1. – negative, ± partially positive, + diffusely positive, PSA Prostate-specific antigen, NGFR Nerve growth factor receptor, FRC Fibroblastic reticular cell, FDC Follicular dendritic cell, EBER-1 (in situ hybridization) Epstein-Barr virus-encoded small RNA-1, ALK Anaplastic lymphoma kinase, EGFR Epidermal growth factor receptor