Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

Table 1 Immunophenotypes of CIRC tumor and small cell carcinoma of this case

Antibody	Immunophenotype
	CIRC tumor		Small cell carcinoma
	Primary tumor	Relapsed tumor	Small cell carcinoma
*Epithelial markers*
CK7	+	–	–
CK8	+	+	±
CK18	+	+	±(weakly)
CAM5.2	+	+	±
AE1/AE3	+	+	±
EMA	+	+	+
34βE12	–	–	–
PSA	–	–	–
NKX3.1	–	–	–
P504S	–	–	–
pCEA	–	–	–
CK5/6	–	–	–
CK20	–	–	–
TTF-1	–	–	±(weakly)
Napsin A	–	–	–
p63	–	–	–
p40	–	–	–
*Neuroendocrine cell markers*
NSE	–	–	+
Chromogranin A	–	–	±
Synaptophysin	–	–	+
CD56	–	–	+
*Lymphoid markers*
CD3	–	–	–
CD4	–	–	–
CD5	–	–	–
CD8	–	–	–
CD20	–	–	–
CD30 (Ki-1)	–	–	–
CD45 (LCA)	–	–	–
CD45RO (UCHL-1)	–	–	–
CD79a	–	–	–
PAX5	–	–	–
EBER-1*	–	–	–
*FRC markers*
Tenascin-C	–	–	–
Prolyl 3-hydroxylase 1	–	–	–
l-caldesmon	+	+	–
Prolyl 4-hydroxylase 1	+	+	–
Lysyl hydroxylase 3	+	+	–
Transglutaminase II	+	+	–
α-SMA	–	–	–
*FDC markers*
CD23	–	–	–
D2–40	–	–	–
Clusterin	–	–	–
CNA.42	–	–	–
NGFR, low affinity	–	–	–
CD21	–	–	–
CD35	–	–	–
*Histiocytic/dendritic cell markers*
CD1a	–	–	–
CD11c	–	–	–
Langerin	–	–	–
DC-SIGN	–	–	–
DC-LAMP	–	–	–
CD83	–	–	–
DEC205	–	–	–
S-100	–	–	–
CD68	–	–	–
Fascin	+	+	–
Factor XIIIa	–	–	–
*Others*
Melan A	–	–	–
HMB45	–	–	–
Desmin	–	–	–
Vimentin	+	+	–
CD34	–	–	–
CD117	–	–	–
ALK	–	–	–
EGFR	< 10%	20%	–
p53	95%	80%	–
Ki-67 (hot spot)	> 75%	15%	< 50%

– negative, ± partially positive, + diffusely positive, PSA Prostate-specific antigen, NGFR Nerve growth factor receptor, FRC Fibroblastic reticular cell, FDC Follicular dendritic cell, EBER-1 (in situ hybridization) Epstein-Barr virus-encoded small RNA-1, ALK Anaplastic lymphoma kinase, EGFR Epidermal growth factor receptor

ISSN: 1746-1596