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Table 2 Clinical data of published CIRC tumors

From: Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

Case No.

Diagnosis

Complication (malignancy)

Age

Sex

Nodal / Extranodal

Region

Size

Treatment

Outcome

References

1

CIRC tumor

 

57

M

Nodal

Left hilum

NA

A left thoracotomy

Radiotherapy; 50 Gy

Alive and well, 9 years

Eur J Cancer 1990; 26: 1121–6

2

CIRC tumor

 

44

M

Nodal

Left hilum

4 cm

A left thoracotomy

Alive and well, over 3 years

3

CIRC tumor

 

61

M

Nodal

Right hilum

NA

A right thoracotomy

Radiotherapy; 50 Gy

Alive and well, 13 months

4

CIRC tumor

 

21

F

Nodal

Mediastinal (superior)

2.5 cm

CHOP chemotherapy

Radiotherapy; 21 Gy

VP-16 and CBDCA chemotherapy

Died of disease, 9 months

Am J Surg Pathol 2000; 24: 107–16

5

CIRC tumor

 

73

F

Extranodal

Right proximal forearm

NA

Surgery (excision)

NA

6

CIRC tumor

 

62

M

Nodal

Mediastinal (posterior)

7.4 cm

Radiotherapy; 65 Gy

NA

7

CIRC tumor

 

66

M

Nodal

Submandibular

1.5 cm

Surgery (excision)

Radiotherapy

Alive and well, 12 months

Histopathology 2003; 43: 491–4

8

FRC tumor (primary)

 

70

F

Nodal

Right submandibular

3.0 cm

Surgery

Died of disease, 10 months

Histopathology 2003; 43: 583–91

CIRC tumor (relapse)

 

Nodal

Local relapse

9.0 cm

VACOP B chemotherapy

Two cycles of CNOP chemotherapy

9

CIRC tumor

Rectal adenocarcinoma

62

M

Extranodal

Spleen

0.9 cm

Surgery (low anterior resection, splenectomy)

Alive and well, 2 years

Int J Surg Pathol 2014; 22: 447–50

10

CIRC tumor with FDC features

 

54

F

Nodal

Right axillary

NA

Surgery (excision)

Alive and well, 2.5 years

Am J Surg Pathol 2015; 39: 573–80

11

CIRC tumor

Uterine endometrioid carcinoma

67

F

Nodal

Pelvic

3.5 cm

Surgery (hysterectomy, bilateral adnexectomy,

pelvic lymphadenectomy)

Alive and well, 9 months

Hum Pathol 2016; 49: 15–21

12

Current case (primary)

 

75

M

Nodal

Mediastinal (superior)

2.7 cm

Surgery (excision)

CBDCA and DOC chemotherapy

Died of disease, 29 months

 

Current case (relapse)

Small cell lung carcinoma

Prostatic latent carcinoma

Extranodal

Right lung apex to the clavicle fossa

1.5 cm

CDDP and VP-16 chemotherapy

Three cycles of NGT chemotherapy

Radiotherapy; 30 Gy

 
  1. CIRC Cytokeratin-positive interstitial reticulum cell, FRC Fibroblastic reticular cell, FDC Follicular dendritic cell, CHOP Cyclophosphamide, doxorubicin, vincristine, and prednisone, VP-16 Etoposide, CBDCA Carboplatin, VACOP-B Etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin, CNOP Cyclophosphamide, mytoxantrone, vincristin, and prednisone, DOC Docetaxel, CDDP Cisplatin, NGT Nogitecan, NA Not available