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Table 3 Reported cases of LEL-HCC

From: Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Reference Age/Sex Race HBV HCV EBV Liver cirrhosis AFP, > 20 ng/mL Tumor location BCLC (0/A) Tumor no. Tumor size(mm) Vascular invasion Treatment Recurrence FU, months Outcomes
An et al [9] 50/M Asian + + + R 1 35 LR Y 6 Alive
Wang et al [13] 37/F NA + + + + R + 1 32 NA LR N 52 Alive
Chen et al [14] 56/M Asian + + + R + 1 32 LR Y 21 Died
Cacciato Insilla et al [15] 81/F NA + + L + 1 72 NA LR N 15 Alive
Shinoda et al [16] 79/M Asian + L + 1 42 LR Y 20 Alive
Wei et al [17] 42/F Asian   + L + 1 46 NA LR N 8 Alive
Park et al [18] 57/M Asian + + R + 1 27 NA LR N 60 Alive
Emil et al [19] 50/M White + + + NA + 1 40 OLT N 120 Alive
  54/M White NA + 2 20 OLT Y 92 Died
  59/M White + + + NA 4 50 OLT N 96 Alive
  45/M White + + NA + 1 20 OLT N 56 Alive
  64/M White + NA 2 40 + OLT N 36 Alive
Si et al [20] 39/F Latino + + + NA NA + 1 10 + OLT Y 5 Died
Nemolato et al [21] 47/F NA NA R + 1 22 NA LR N 15 Alive
Shirabe et al [22] 58/F Asian + NA + + R + 1 22 NA LR N 78 Alive
Patel et al [23] 74/F White NA Multi 65 + LR Y 24 Died
  65/M White NA + 1 48 LR N 60 Died
  65/F White + NA + 1 13 LR N 108 Alive
  70/F White + NA + 1 27 LR N 72 Alive
  61/F White NA Multi 95 + LR N 4 Died
  78/M White NA + 1 105 + LR Y 48 Alive
  78/F White NA + 1 60 LR N 24 Alive
  57/F White NA 1 130 + LR N 1 Died
Chan et al [24] 58a/13 M, 7F NA 17/20 0 0 8+/20 13/20 NA 20+/20 1 38 NA LR NA 5-y survival: 88%
Wada et al [11] 62a/10 M, 1F NA 0/11 11/11 / 6/11 NA NA NA NA 22 1+/11 LR NA 5-y survival: 100%
  1. Calderaro et al. mentioned 13 cases of LEL-HCC treated with liver resection for hepatocellular carcinoma, but no relevant information was provided.
  2. F female, M male, + positive, − negative, AFP a-fetoprotein, NA not available, HBV hepatitis B virus, HCV hepatitis C virus, EBV Epstein-Barr virus, no. number, R right liver, L left liver, LR liver resection, CT chemotherapy, OLT orthotopic liver transplant, N NO, Y Yes, FU follow-up, mo. months, aIndicated as the mean value