Table 1 Summary of the clinicopathologic features of T-cell lymphoproliferative disorder following autologous hematopoietic stem cell transplantation
Age at onset of first neoplasm | Histological diagnosis of first neoplasm | Therapy before AutoHSCT | Histological diagnosis of T-cell LPD | Histological findings | EBV (ISH or PCR) | Areas of T-cell LPD | Time of T-cell LPD onset after HSCT | Outcome | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 48 years | HL | (1) Doxorubicin-based chemotherapy (2) High-dose cytosine arabinoside (3) Conditioning regimen that included cyclophosphamide, etoposide, and ranimustine | T-cell PTLD | (Lymph node) Lymphoid hyperplasia with mild sinus histiocytosis, as well as proliferation of epithelioid cells. | Positive | Mesenteric lymph nodes | 2 years and 6 months | Fatal | [12] |
2 | 61 years | AITL | (1) Four cycles of CHOP (2) High-dose etoposide (3) Two cycles of CHOP (4) Ranimustine, cyclophosphamide, etoposide, and carboplatin | T-LGL | (Blood) Pronounced lymphocytosis of large-sized lymphoid cells with round to indented nuclei, coarse chromatin, and azurophilic cytoplasmic granules. | Negative | Bone marrow | 1 month | Survival | [13] |
3 | 62 years | FL | (1) Eight cycles of CHOP (2) Two cycles of MINE (3) Etoposide (4) Ranimustine, carboplatin, etoposide, and cyclophosphamide | AITL | (Lymph node) Diffuse infiltration of medium to large-sized lymphoid cells with predominant proliferation of small blood vessels. | Positive | Cervical and supraclavicular lymph nodes | 4 months | Resolved | [14] |
4 | 49 years | AITL | (1) Five cycles of CHOP (2) Salvage chemotherapy: ESHAP (3) MCVAC | T-cell PTLD | (Autopsy) Lymphoid cells in the bone marrow, portal area of the liver, lymph nodes and lungs. The hypocellularity in the marrow with the proliferation of macrophages and marked hemophagocytosis. Macrophages in the marrow, liver, lymph nodes, and lungs. | Positive | Bone marrow, liver, lungs, lymph nodes | 3 months | Fatal | [15] |
5 | 47 years | DLBCL | High-dose radiotherapy and chemotherapy | Enteropathy type T-cell lymphoma | (Jejunum) An atypical destructive lymphoid infiltration with intraepithelial lymphocytes in the superficial mucosa and in the glands. | Negative | Jejunum, duodenum, mesenteric lymph nodes | 6 years and 3 months | Resolved | [16] |
6 | 53 years | MM | (1) Three cycles of VAD (2) High-dose melphalan: Prednisolone and cyclosporin A for erythroderma | AITL | (Lymph node) Nodular infiltration of atypical lymphocytes with large nucleoli. | Positive | Brain, axillary and inguinal lymph nodes | 10 months | Resolved | [17] |
Our case | 53 years | DLBCL | (1) Six cycle of R-CHOP (2) Three cycles of R-ACES | PTCL-NOS | (Lung) Diffuse infiltration of small to medium-sized lymphocytes with multiple granulomas. | Positive | Supraclavicular, mediastinal, hilar, paraaortic, mesenteric lymph nodes, lungs | 4 years | Fatal |