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Fig. 6 | Diagnostic Pathology

Fig. 6

From: Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3

Fig. 6

CDCA3 overexpression reversed the inhibitory effects of circ_0001421 knockdown on LC cell proliferation, migration, invasion and glycolysis. a The protein of CDCA3 in H1299 and A549 cells transfected with Vector or CDCA3 was detected by western blot. b-g H1299 and A549 cells were transfected with si-NC, si-circ_0001421, si-circ_0001421 + Vector or si-circ_0001421 + CDCA3. b Cell proliferation was assessed by MTT assay. c-d Cell migration and invasion were assessed by Transwell assay. e-f Glucose consumption and lactate production were appraised via a Glucose assay kit and a Lactic Acid assay kit. g Western blot was performed to check the protein expression of HK2. *P < 0.05

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