KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics

Table 3 Expression and extent of KPNA2 Immunohistochemical staining in osteosarcoma subtypes

Osteosarcoma subtype	Positives Cases^b (%)	Extent of staining^a						Strong-intensity staining (%)
Osteosarcoma subtype	Positives Cases^b (%)	0	1+	2+	3+	4+	5+	Strong-intensity staining (%)
Osteoblastic (n = 55)	50 (90.9)	3	2	13	18	15	4	39 (70.9)
Chondroblastic (n = 13)	10 (76.9)	2	1	3	4	2	1	7 (53.8)
Fibroblastic (n = 6)	2 (33.3)	3	1	0	2	0	0	2 (33.3)
Telangiectatic (n = 4)	3 (75)	1	0	1	2	0	0	2 (50)
giant cell-rich (n = 3)	2 (66.7)	1	0	1	1	0	0	1 (33.3)
Total (n = 81)	67 (82.7)	10	4	18	27	17	5	51 (63.0)

^a0, no staining; 1+, < 5%; 2+, 5–25%; 3+, 26–50%; 4+, 51–75%;5+, 76–100%
^bThe positive KPNA2 staining was defined as nucleus staining in at least 5% cells

ISSN: 1746-1596