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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway

Fig. 3

Circ_0003998 is a sponge of miR-218-5p. a The potential binding sites of circ_0003998 and miR-218-5p. b, c Dual-luciferase reporter assay in Huh7/DOX and HCCLM3/DOX cells co-transfected with the reporter plasmid and the indicated miRNAs. d-f qRT-PCR analysis of miR-218-5p in HCC tissues, DOX-resistant tissues and matched normal tissues (d), normal hepatocyte THLE-2 and HCC cell lines (Hep3B, Huh7 and HCCLM3) (e), as well as DOX-resistant HCC cell lines and parental HCC cells (f). g qRT-PCR analysis of miR-218-5p in Huh7/DOX and HCCLM3/DOX transfected with si-NC or si-circ_0003998. h Correlation analysis between circ_0003998 and miR-218-5p expression. *P < 0.05

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