Fig. 8

Circ_0003998 silence enhances the cytotoxicity of DOX on HCC cells in vivo. a Tumor volumes were calculated every 4 days. b Mice were sacrifice on day 27 and tumor masses were excised and weighed. c-e The expression of circ_0003998, miR-218-5p and EIF5A2 mRNA in the tumor tissues in each group quantified using qRT-PCR. f Protein expression of EIF5A2 in the tumor tissues in each group quantified using western blot. *P < 0.05