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Table 1 Immunohistochemical findings of this case

From: Nodal histiocytic sarcoma with prominent eosinophilic infiltration: expression of eotaxin-2 on tumor cells

Markers Neoplastic cells Intratumoral eosinophils
Histiocytic marker CD68 +
CD163 +
LN5 +
LIGHT +
PD-L1 +
Lysozyme partially +
LN2 partially +
LN3 partially +
DC-SIGN partially +
HO-1
CD205 (DEC205)
CD208 (DC-LAMP)
Langerhans cell marker S-100 protein
CD1a
Langerin
FDC marker CD21
CD23
CD35
Clusterin
Epithelial cell marker Cytokeratins
EMA
Lymphocyte marker CD3
CD4
CD5
CD8
CD10
CD20
CD30
CD56
PAX5
PD-1
Melanoma marker HMB45
Melan A
Neuroendocrine marker chromogranin A
synaptophysin
Mesenchymal cell marker caldesmon
desmin
α-SMA
Others Eotaxin-2 + +
Eotaxin-3 +
  1. FDC, follicular dendritic cell; LIGHT, homologous to lymphotoxin, inducible expression, competes with herpes simplex virus [HSV] glycoprotein D for binding to HSV entry mediator, a receptor expressed on T lymphocytes]/CD258/TNFSF14; HO-1, heme oxygenase 1