Table 1 Immunohistochemical findings of this case
Markers | Neoplastic cells | Intratumoral eosinophils | |
|---|---|---|---|
Histiocytic marker | CD68 | + | – |
CD163 | + | – | |
LN5 | + | – | |
LIGHT | + | – | |
PD-L1 | + | – | |
Lysozyme | partially + | – | |
LN2 | partially + | – | |
LN3 | partially + | – | |
DC-SIGN | partially + | – | |
HO-1 | – | – | |
CD205 (DEC205) | – | – | |
CD208 (DC-LAMP) | – | – | |
Langerhans cell marker | S-100 protein | – | – |
CD1a | – | – | |
Langerin | – | – | |
FDC marker | CD21 | – | – |
CD23 | – | – | |
CD35 | – | – | |
Clusterin | – | – | |
Epithelial cell marker | Cytokeratins | – | – |
EMA | – | – | |
Lymphocyte marker | CD3 | – | – |
CD4 | – | – | |
CD5 | – | – | |
CD8 | – | – | |
CD10 | – | – | |
CD20 | – | – | |
CD30 | – | – | |
CD56 | – | – | |
PAX5 | – | – | |
PD-1 | – | – | |
Melanoma marker | HMB45 | – | – |
Melan A | – | – | |
Neuroendocrine marker | chromogranin A | – | – |
synaptophysin | – | – | |
Mesenchymal cell marker | caldesmon | – | – |
desmin | – | – | |
α-SMA | – | – | |
Others | Eotaxin-2 | + | + |
Eotaxin-3 | – | + | |