|
Markers
|
Neoplastic cells
|
Intratumoral eosinophils
|
|---|
|
Histiocytic marker
|
CD68
|
+
|
–
|
|
CD163
|
+
|
–
|
|
LN5
|
+
|
–
|
|
LIGHT
|
+
|
–
|
|
PD-L1
|
+
|
–
|
|
Lysozyme
|
partially +
|
–
|
|
LN2
|
partially +
|
–
|
|
LN3
|
partially +
|
–
|
|
DC-SIGN
|
partially +
|
–
|
|
HO-1
|
–
|
–
|
|
CD205 (DEC205)
|
–
|
–
|
|
CD208 (DC-LAMP)
|
–
|
–
|
|
Langerhans cell marker
|
S-100 protein
|
–
|
–
|
|
CD1a
|
–
|
–
|
|
Langerin
|
–
|
–
|
|
FDC marker
|
CD21
|
–
|
–
|
|
CD23
|
–
|
–
|
|
CD35
|
–
|
–
|
|
Clusterin
|
–
|
–
|
|
Epithelial cell marker
|
Cytokeratins
|
–
|
–
|
|
EMA
|
–
|
–
|
|
Lymphocyte marker
|
CD3
|
–
|
–
|
|
CD4
|
–
|
–
|
|
CD5
|
–
|
–
|
|
CD8
|
–
|
–
|
|
CD10
|
–
|
–
|
|
CD20
|
–
|
–
|
|
CD30
|
–
|
–
|
|
CD56
|
–
|
–
|
|
PAX5
|
–
|
–
|
|
PD-1
|
–
|
–
|
|
Melanoma marker
|
HMB45
|
–
|
–
|
|
Melan A
|
–
|
–
|
|
Neuroendocrine marker
|
chromogranin A
|
–
|
–
|
|
synaptophysin
|
–
|
–
|
|
Mesenchymal cell marker
|
caldesmon
|
–
|
–
|
|
desmin
|
–
|
–
|
|
α-SMA
|
–
|
–
|
|
Others
|
Eotaxin-2
|
+
|
+
|
|
Eotaxin-3
|
–
|
+
|
- FDC, follicular dendritic cell; LIGHT, homologous to lymphotoxin, inducible expression, competes with herpes simplex virus [HSV] glycoprotein D for binding to HSV entry mediator, a receptor expressed on T lymphocytes]/CD258/TNFSF14; HO-1, heme oxygenase 1
