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Fig. 4 | Diagnostic Pathology

Fig. 4

From: High miR-324-5p expression predicts unfavorable prognosis of gastric cancer and facilitates tumor progression in tumor cells

Fig. 4

PTEN directly mediated the regulatory effects of miR-324-5p on AGS cell proliferation, apoptosis, migration and invasion. a. The putative binding site of miR-324-5p at the 3′-UTR of PTEN. b. The relative luciferase activity in AGS cells in the dual-luciferase reporter assay. c. The mRNA expression of PTEN was inhibited by miR-324-5p overexpression, and the pcDNA3.1-PTEN could reverse this effect. d-g. The promoted cell proliferation, inhibited cell apoptosis and enhanced cell migration and invasion induced by miR-324-5p overexpression were all abolished by the upregulation of PTEN in AGS cells. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control group; #P < 0.05, ##P < 0.01 compared to miR-324-5p mimic group

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