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Table 2 Clinicopathologic variables and the expression of IL4Rα and IL13Rα1 in soft-tissue sarcomas

From: Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum

Characteristics

No.

nIL4Rα

cIL4Rα

nIL13Rα1

cIL13Rα1

positive

p

positive

p

positive

p

positive

p

Age, y

< 60

56

26 (46%)

0.033

33 (59%)

0.310

26 (46%)

0.310

22 (39%)

0.162

≥ 60

33

23 (70%)

 

23 (70%)

 

19 (58%)

 

18 (55%)

 

Sex

Female

37

19 (51%)

0.553

22 (59%)

0.568

15 (41%)

0.111

13 (35%)

0.117

Male

52

30 (58%)

 

34 (65%)

 

30 (58%)

 

27 (52%)

 

Stage

I and II

36

12 (33%)

< 0.001

17 (47%)

0.012

8 (22%)

< 0.001

12 (33%)

0.070

III and IV

53

37 (70%)

 

39 (74%)

 

37 (70%)

 

28 (53%)

 

Tumor size

≤ 5 cm

35

15 (43%)

0.063

20 (57%)

0.364

14 (40%)

0.109

16 (46%)

0.906

> 5 cm

54

34 (63%)

 

36 (67%)

 

31 (57%)

 

24 (44%)

 

LN metastasis

Absence

77

39 (51%)

0.034

45 (58%)

0.027

35 (45%)

0.015

34 (44%)

0.705

Presence

12

10 (83%)

 

11 (92%)

 

10 (83%)

 

6 (50%)

 

Distant metastasis

Absence

65

32 (49%)

0.069

38 (58%)

0.152

23 (35%)

< 0.001

26 (40%)

0.123

Presence

24

17 (71%)

 

18 (75%)

 

22 (92%)

 

14 (58%)

 

Histological grade

Low

18

4 (22%)

0.002

5 (28%)

< 0.001

2 (11%)

< 0.001

4 (22%)

0.030

High

71

45 (63%)

 

51 (72%)

 

43 (61%)

 

36 (51%)

 

Tumor differentiation

1

7

4 (57%)

0.908

4 (57%)

0.742

2 (29%)

0.742

1 (14%)

0.225

2 and 3

82

45 (55%)

 

52 (63%)

 

52 (63%)

 

43 (52%)

 

Mitotic count

0–9/10 HPF

36

12 (33%)

< 0.001

16 (44%)

0.003

11 (31%)

0.002

13 (36%)

0.167

> 9/10 HPF

53

37 (70%)

 

40 (75%)

 

34 (64%)

 

27 (51%)

 

Tumor necrosis

Absence

48

21 (44%)

0.020

25 (52%)

0.022

16 (33%)

< 0.001

17 (35%)

0.051

Presence

41

28 (68%)

 

31 (76%)

 

29 (71%)

 

23 (56%)

 

cIL13Rα1

Negative

49

20 (41%)

0.003

23 (47%)

< 0.001

14 (29%)

   

Positive

40

29 (73%)

 

33 (83%)

 

31 (78%)

< 0.001

  

nIL13Rα1

Negative

44

13 (30%)

< 0.001

18 (41%)

< 0.001

    

Positive

45

36 (80%)

 

38 (84%)

     

cIL4Rα

Negative

33

3 (9%)

< 0.001

      

Positive

56

46 (82%)

       
  1. Abbreviations: nIL4Rα Nuclear expression of IL4Rα, cIL4Rα Cytoplasmic expression of IL4Rα, nIL13Rα1 nuclear expression of IL13Rα1, cIL13Rα1 Cytoplasmic expression of IL13Rα1
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Diagnostic Pathology

ISSN: 1746-1596

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