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Table 2 Clinicopathologic variables and the expression of IL4Rα and IL13Rα1 in soft-tissue sarcomas

From: Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum

Characteristics No. nIL4Rα cIL4Rα nIL13Rα1 cIL13Rα1
positive p positive p positive p positive p
Age, y < 60 56 26 (46%) 0.033 33 (59%) 0.310 26 (46%) 0.310 22 (39%) 0.162
≥ 60 33 23 (70%)   23 (70%)   19 (58%)   18 (55%)  
Sex Female 37 19 (51%) 0.553 22 (59%) 0.568 15 (41%) 0.111 13 (35%) 0.117
Male 52 30 (58%)   34 (65%)   30 (58%)   27 (52%)  
Stage I and II 36 12 (33%) < 0.001 17 (47%) 0.012 8 (22%) < 0.001 12 (33%) 0.070
III and IV 53 37 (70%)   39 (74%)   37 (70%)   28 (53%)  
Tumor size ≤ 5 cm 35 15 (43%) 0.063 20 (57%) 0.364 14 (40%) 0.109 16 (46%) 0.906
> 5 cm 54 34 (63%)   36 (67%)   31 (57%)   24 (44%)  
LN metastasis Absence 77 39 (51%) 0.034 45 (58%) 0.027 35 (45%) 0.015 34 (44%) 0.705
Presence 12 10 (83%)   11 (92%)   10 (83%)   6 (50%)  
Distant metastasis Absence 65 32 (49%) 0.069 38 (58%) 0.152 23 (35%) < 0.001 26 (40%) 0.123
Presence 24 17 (71%)   18 (75%)   22 (92%)   14 (58%)  
Histological grade Low 18 4 (22%) 0.002 5 (28%) < 0.001 2 (11%) < 0.001 4 (22%) 0.030
High 71 45 (63%)   51 (72%)   43 (61%)   36 (51%)  
Tumor differentiation 1 7 4 (57%) 0.908 4 (57%) 0.742 2 (29%) 0.742 1 (14%) 0.225
2 and 3 82 45 (55%)   52 (63%)   52 (63%)   43 (52%)  
Mitotic count 0–9/10 HPF 36 12 (33%) < 0.001 16 (44%) 0.003 11 (31%) 0.002 13 (36%) 0.167
> 9/10 HPF 53 37 (70%)   40 (75%)   34 (64%)   27 (51%)  
Tumor necrosis Absence 48 21 (44%) 0.020 25 (52%) 0.022 16 (33%) < 0.001 17 (35%) 0.051
Presence 41 28 (68%)   31 (76%)   29 (71%)   23 (56%)  
cIL13Rα1 Negative 49 20 (41%) 0.003 23 (47%) < 0.001 14 (29%)    
Positive 40 29 (73%)   33 (83%)   31 (78%) < 0.001   
nIL13Rα1 Negative 44 13 (30%) < 0.001 18 (41%) < 0.001     
Positive 45 36 (80%)   38 (84%)      
cIL4Rα Negative 33 3 (9%) < 0.001       
Positive 56 46 (82%)        
  1. Abbreviations: nIL4Rα Nuclear expression of IL4Rα, cIL4Rα Cytoplasmic expression of IL4Rα, nIL13Rα1 nuclear expression of IL13Rα1, cIL13Rα1 Cytoplasmic expression of IL13Rα1