Table 3 Univariate Cox proportional hazards regression analysis of overall survival and relapse-free survival in soft-tissue sarcoma patients
Characteristics | No. | OS | RFS | ||
|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | ||
Sex, male (vs. female) | 52/89 | 1.598 (0.834–3.064) | 0.158 | 1.239 (0.724–2.118) | 0.435 |
Age, ≥ 60 (vs. < 60) | 23/89 | 1.330 (0.705–2.512) | 0.379 | 1.714 (1.007–2.917) | 0.047 |
Stage, III and IV (vs. I and II) | 53/89 | 4.540 (1.986–10.375) | < 0.001 | 2.342 (1.303–4.208) | 0.004 |
Tumor size, > 5 cm (vs. ≤ 5 cm) | 54/89 | 1.582 (0.802–3.120) | 0.186 | 1.157 (0.672–1.991) | 0.600 |
LN metastasis, presence (vs. absence) | 12/89 | 2.834 (1.340–5.994) | 0.006 | 2.076 (1.043–4.134) | 0.038 |
Distant metastasis, presence (vs. absence) | 24/89 | 5.976 (3.152–11.331) | < 0.001 | 4.097 (2.351–7.139) | < 0.001 |
Histological grade, high (vs. low) | 71/89 | 16.434 (2.237–120.748) | 0.006 | 3.313 (1.411–7.777) | 0.006 |
Tumor differentiation, 2 and 3 (vs. 1) | 82/89 | 2.041 (0.491–8.481) | 0.326 | 0.899 (0.357–2.260) | 0.820 |
Mitotic count, ≥ 10/10 HPF (vs. 0–9/10 HPF) | 53/89 | 3.548 (1.620–7.772) | 0.002 | 2.196 (1.225–3.937) | 0.008 |
Tumor necrosis, presence (vs. absence) | 41/89 | 4.792 (2.331–9.853) | < 0.001 | 2.209 (1.294–3.771) | 0.004 |
nIL4Rα, positive (vs. negative) | 49/89 | 5.249 (2.398–11.493) | < 0.001 | 3.750 (2.051–6.855) | < 0.001 |
cIL4Rα, positive (vs. negative) | 56/89 | 4.099 (1.799–9.339) | < 0.001 | 3.394 (1.782–6.464) | < 0.001 |
nIL13Rα1, positive (vs. negative) | 45/89 | 9.451 (3.938–22.683) | < 0.001 | 6.546 (3.499–12.248) | < 0.001 |
cIL13Rα1, positive (vs. negative) | 40/89 | 2.902 (1.510–5.579) | 0.001 | 2.305 (1.353–3.924) | 0.002 |