Skip to main content

Table 3 Univariate Cox proportional hazards regression analysis of overall survival and relapse-free survival in soft-tissue sarcoma patients

From: Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum

Characteristics No. OS RFS
HR (95% CI) p HR (95% CI) p
Sex, male (vs. female) 52/89 1.598 (0.834–3.064) 0.158 1.239 (0.724–2.118) 0.435
Age, ≥ 60 (vs. < 60) 23/89 1.330 (0.705–2.512) 0.379 1.714 (1.007–2.917) 0.047
Stage, III and IV (vs. I and II) 53/89 4.540 (1.986–10.375) < 0.001 2.342 (1.303–4.208) 0.004
Tumor size, > 5 cm (vs. ≤ 5 cm) 54/89 1.582 (0.802–3.120) 0.186 1.157 (0.672–1.991) 0.600
LN metastasis, presence (vs. absence) 12/89 2.834 (1.340–5.994) 0.006 2.076 (1.043–4.134) 0.038
Distant metastasis, presence (vs. absence) 24/89 5.976 (3.152–11.331) < 0.001 4.097 (2.351–7.139) < 0.001
Histological grade, high (vs. low) 71/89 16.434 (2.237–120.748) 0.006 3.313 (1.411–7.777) 0.006
Tumor differentiation, 2 and 3 (vs. 1) 82/89 2.041 (0.491–8.481) 0.326 0.899 (0.357–2.260) 0.820
Mitotic count, ≥ 10/10 HPF (vs. 0–9/10 HPF) 53/89 3.548 (1.620–7.772) 0.002 2.196 (1.225–3.937) 0.008
Tumor necrosis, presence (vs. absence) 41/89 4.792 (2.331–9.853) < 0.001 2.209 (1.294–3.771) 0.004
nIL4Rα, positive (vs. negative) 49/89 5.249 (2.398–11.493) < 0.001 3.750 (2.051–6.855) < 0.001
cIL4Rα, positive (vs. negative) 56/89 4.099 (1.799–9.339) < 0.001 3.394 (1.782–6.464) < 0.001
nIL13Rα1, positive (vs. negative) 45/89 9.451 (3.938–22.683) < 0.001 6.546 (3.499–12.248) < 0.001
cIL13Rα1, positive (vs. negative) 40/89 2.902 (1.510–5.579) 0.001 2.305 (1.353–3.924) 0.002
  1. Abbreviations: OS Overall survival, RFS Relapse-free survival, HR Hazard ratio, 95% CI 95% confidence interval, nIL4Rα Nuclear expression of IL4Rα, cIL4Rα Cytoplasmic expression of IL4Rα, nIL13Rα1 Nuclear expression of IL13Rα1, cIL13Rα1 Cytoplasmic expression of IL13Rα1