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Table 6 Univariate and multivariate Cox regression analysis of overall survival and relapse-free survival according to the co-expression patterns of nuclear IL4Rα and nuclear IL13Rα1 in soft-tissue sarcomas

From: Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum

Characteristics No. OS RFS
HR (95% CI) p HR (95% CI) p
Univariate analysis
 nIL4Rα/nIL13Rα1, −/− 31/89 1 < 0.001 1 < 0.001
  +/− 13/89 3.230 (0.640–16.303) 0.156 2.990 (1.048–8.535) 0.041
  −/+ 9/89 7.673 (1.916–30.738) 0.004 7.670 (2.770–21.237) < 0.001
  +/+ 36/89 18.871 (5.553–64.130) < 0.001 10.815 (4.648–25.169) < 0.001
 nIL4Rα/nIL13Rα1, −/− 31/89 1 < 0.001 1 < 0.001
  +/− or −/+ 22/89 5.355 (1.434–20.004) 0.013 4.424 (1.801–10.871) 0.001
  +/+ 36/89 19.504 (5.671–67.080) < 0.001 10.791 (4.633–25.134) < 0.001
Multivariate analysis Model 1
 Distant metastasis, presence (vs. absence)   3.743 (1.762–7.952) < 0.001 2.083 (1.127–3.849) 0.019
 nIL4Rα/nIL13Rα1, −/−   1 < 0.001 1 < 0.001
  +/−   3.140 (0.626–15.760) 0.165 2.972 (1.041–8.486) 0.042
  −/+   2.808 (0.610–12.924) 0.185 4.827 (1.601–14.551) 0.005
  +/+   11.927 (3.359–42.353) < 0.001 8.729 (3.628–21.003) < 0.001
Multivariate analysis Model 2
 Distant metastasis, presence (vs. absence)   3.663 (1.836–7.307) < 0.001 2.312 (1.305–4.095) 0.004
 nIL4Rα/nIL13Rα1, −/−   1 < 0.001 1 < 0.001
  +/− or −/+   2.947 (0.750–11.584) 0.122 3.619 (1.447–9.052) 0.006
  +/+   12.004 (3.396–42.433) < 0.001 8.397 (3.491–20.197) < 0.001
  1. Abbreviations: OS Overall survival, RFS Relapse-free survival, HR Hazard ratio, 95% CI 95% confidence interval, nIL4Rα Nuclear expression of IL4Rα, cIL4Rα; nIL13Rα1 Nuclear expression of IL13Rα1