Table 3 Univariate analysis of GSTM3 expression and clinicopathological factors for DSS and DFS in mRNA cohort patients with ESCC
Characteristic | Cases | Disease-specific survival (DSS) (%) | P# | Disease-free survival (DFS) (%) | P# | ||
|---|---|---|---|---|---|---|---|
3-year DSS | 5-year DSS | 3-year DFS | 5-year DFS | ||||
Gender | 0.450 | 0.830 | |||||
Male | 135 | 60.6 | 50.8 | 49.2 | 37.1 | ||
Female | 49 | 58.2 | 44.5 | 46.7 | 34.9 | ||
Age | 0.096 | 0.382 | |||||
≤ 60 | 104 | 64.5 | 53.6 | 53.5 | 40.6 | ||
> 60 | 80 | 54.3 | 43.8 | 42.3 | 31.3 | ||
Location | 0.228 | 0.500 | |||||
Upper | 40 | 53.9 | 40.0 | 44.0 | 34.9 | ||
Middle | 100 | 59.8 | 50.7 | 48.2 | 34.4 | ||
Lower | 44 | 65.6 | 52.3 | 53.4 | 43.1 | ||
Differentiation | 0.217 | 0.048 | |||||
Grade 1 | 46 | 68.8 | 59.6 | 61.6 | 49.9 | ||
Grade 2 | 92 | 61.5 | 47.8 | 47.4 | 33.2 | ||
Grade 3 | 46 | 47.2 | 41.5 | 37.5 | 30.0 | ||
pT category | 0.064 | 0.098 | |||||
T1-2 | 44 | 67.8 | 61.4 | 57.0 | 48.3 | ||
T3-4 | 140 | 57.4 | 45.4 | 45.9 | 32.9 | ||
pN category | 0.000 | 0.000 | |||||
N0 | 100 | 76.9 | 65.7 | 69.2 | 53.6 | ||
N1-3 | 84 | 40.0 | 30.0 | 25.0 | 17.3 | ||
Pathological staging | 0.000 | 0.000 | |||||
I | 13 | 92.3 | 80.8 | 92.3 | 71.2 | ||
II | 92 | 72.3 | 61.8 | 62.8 | 50.1 | ||
III | 79 | 40.2 | 29.6 | 25.4 | 15.8 | ||
GSTM3 expression | 0.132 | 0.016 | |||||
Low | 91 | 56.2 | 46.0 | 39.2 | 26.8 | ||
High | 93 | 64.6 | 52.8 | 57.4 | 45.1 | ||