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Table 1 Pathologic characteristics of clear cell carcinoma and their association with MMR status

From: Mismatch repair deficiency is associated with specific morphologic features and frequent loss of ARID1A expression in ovarian clear cell carcinoma

 

MMR-deficient cases (n = 10)

MMR-intact cases (n = 166)

P

Age(y)

  

0.078

 <50

6 (60 %)

54 (32.5 %)

 

 ≥50

4 (40 %)

112 (67.5 %)

 

Median

46

53

0.041

Family history of cancer

2

39

1.0

HNPCC history

2

20

0.362

Precursor

 Not present

Adenofibroma

Endometriosis

both

4 (40 %)

1 (10 %)

4 (40 %)

1 (10 %)

61 (36.7 %)

22 (13.3 %)

69 (41.6 %)

14 (8.4 %)

0.987

Stromal Hyalinization

  

0.671

Focal or absent

8 (80 %)

139 (83.7 %)

 

Diffuse

2 (20 %)

27 (16.3 %)

 

Nuclear Atypia

  

0.139

High grade

5 (50 %)

43 (25.9 %)

 

Low-medium grade

5 (50 %)

123 (74.1 %)

 

Signet ring cells

  

0.603

Not present

10 (100 %)

147 (88.6 %)

 

Present

0 (0 %)

19 (11.4 %)

 

Peritumoral Lymphocytes

  

0.127

Not present

7 (70 %)

146 (88 %)

 

Present

3 (30 %)

20 (12 %)

 

Intratumoral Stromal Inflammation

  

0.001

Diffuse

5 (50 %)

11 (6.6 %)

 

Focal

5 (50 %)

155 (93.4 %)

 

Plasma Cell Component

  

0.037

≤50 %

6 (60 %)

145 (87.3 %)

 

>50 %

4 (40 %)

21 (12.7 %)

 

Tumor infiltrating Lymphocytes (/10HPF)

  

0.249

< 40

8 (80 %)

151 (91 %)

 

≥ 40

2 (20 %)

15 (9 %)

 

Mitosis (/10HPF)

5.1

6.4

0.499

Necrosis

  

0.300

Not present

3 (30 %)

73 (44 %)

 

Present

7 (70 %)

93 (56 %)

 

ARID1A (135 cases)

  

0.027

Negative

8 (80 %)

54 (43.2 %)

 

Positive

2 (20 %)

71 (56.8 %)

 

Stage

  

0.462

I/II

6

110

 

III-IV

4

56