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Table 1 Pathologic characteristics of clear cell carcinoma and their association with MMR status

From: Mismatch repair deficiency is associated with specific morphologic features and frequent loss of ARID1A expression in ovarian clear cell carcinoma

  MMR-deficient cases (n = 10) MMR-intact cases (n = 166) P
Age(y)    0.078
 <50 6 (60 %) 54 (32.5 %)  
 ≥50 4 (40 %) 112 (67.5 %)  
Median 46 53 0.041
Family history of cancer 2 39 1.0
HNPCC history 2 20 0.362
Precursor
 Not present
Adenofibroma
Endometriosis
both
4 (40 %)
1 (10 %)
4 (40 %)
1 (10 %)
61 (36.7 %)
22 (13.3 %)
69 (41.6 %)
14 (8.4 %)
0.987
Stromal Hyalinization    0.671
Focal or absent 8 (80 %) 139 (83.7 %)  
Diffuse 2 (20 %) 27 (16.3 %)  
Nuclear Atypia    0.139
High grade 5 (50 %) 43 (25.9 %)  
Low-medium grade 5 (50 %) 123 (74.1 %)  
Signet ring cells    0.603
Not present 10 (100 %) 147 (88.6 %)  
Present 0 (0 %) 19 (11.4 %)  
Peritumoral Lymphocytes    0.127
Not present 7 (70 %) 146 (88 %)  
Present 3 (30 %) 20 (12 %)  
Intratumoral Stromal Inflammation    0.001
Diffuse 5 (50 %) 11 (6.6 %)  
Focal 5 (50 %) 155 (93.4 %)  
Plasma Cell Component    0.037
≤50 % 6 (60 %) 145 (87.3 %)  
>50 % 4 (40 %) 21 (12.7 %)  
Tumor infiltrating Lymphocytes (/10HPF)    0.249
< 40 8 (80 %) 151 (91 %)  
≥ 40 2 (20 %) 15 (9 %)  
Mitosis (/10HPF) 5.1 6.4 0.499
Necrosis    0.300
Not present 3 (30 %) 73 (44 %)  
Present 7 (70 %) 93 (56 %)  
ARID1A (135 cases)    0.027
Negative 8 (80 %) 54 (43.2 %)  
Positive 2 (20 %) 71 (56.8 %)  
Stage    0.462
I/II 6 110  
III-IV 4 56