Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

Diagnostic Pathology

Table 6 Clinical performance of various indicators for detection of CIN2/3

	Pathological diagnosis		Sensitivity	P	Specificity	P
	LSIL (n = 27)	HISL (n = 33)	Sensitivity	P	Specificity	P
E6/E7mRNA
+	3	32	96.97%	0.555	88.89%	0.444
-	24	1	96.97%	0.555	88.89%	0.444
p16
+	5	31	93.94%	0.555	81.48%	0.444
-	22	2	93.94%	0.555	81.48%	0.444
p16/Ki67
+	4	30	90.91%	0.302	85.19%	0.685
-	23	3	90.91%	0.302	85.19%	0.685
E6/E7mRNA/p16
+	2	30	90.91%	0.302	92.59%	0.639
-	25	3	90.91%	0.302	92.59%	0.639
E6/E7mRNA/Ki67
+	3	31	93.94%	0.555	88.89%	1.000
-	24	2	93.94%	0.555	88.89%	1.000
E6/E7mRNA/p16/Ki67
+	2	29	87.88%	0.163	92.59%	0.639
-	25	4	87.88%	0.163	92.59%	0.639

ISSN: 1746-1596