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Table 6 Clinical performance of various indicators for detection of CIN2/3

From: Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

  Pathological diagnosis Sensitivity P Specificity P
LSIL (n = 27) HISL (n = 33)
E6/E7mRNA
 + 3 32 96.97% 0.555 88.89% 0.444
 - 24 1
p16
 + 5 31 93.94% 0.555 81.48% 0.444
 - 22 2
p16/Ki67
 + 4 30 90.91% 0.302 85.19% 0.685
 - 23 3
E6/E7mRNA/p16
 + 2 30 90.91% 0.302 92.59% 0.639
 - 25 3
E6/E7mRNA/Ki67
 + 3 31 93.94% 0.555 88.89% 1.000
 - 24 2
E6/E7mRNA/p16/Ki67
 + 2 29 87.88% 0.163 92.59% 0.639
 - 25 4